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Antibody-independent effector mechanisms in resistance to the intestinal nematode parasite Trichuris muris.抗肠道线虫寄生虫毛首鞭形线虫的抗体非依赖效应机制
Infect Immun. 1996 Aug;64(8):2950-4. doi: 10.1128/iai.64.8.2950-2954.1996.
2
Characterisation of the protective immune response following subcutaneous vaccination of susceptible mice against Trichuris muris.皮下接种易感小鼠对抗旋毛虫的保护性免疫应答的特征。
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3
Trickle infection and immunity to Trichuris muris.滴注感染和对旋毛虫的免疫力。
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4
Regulatory T cells limit induction of protective immunity and promote immune pathology following intestinal helminth infection.调节性 T 细胞限制了保护性免疫的诱导，并促进了肠道寄生虫感染后的免疫病理。
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Mast cells, eosinophils and antibody-mediated cellular cytotoxicity are not critical in resistance to Trichuris muris.肥大细胞、嗜酸性粒细胞和抗体介导的细胞毒性在抵抗鼠鞭虫感染中并不关键。
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Mucosal mast cell responses are not required for protection against infection with the murine nematode parasite Trichuris muris.抵抗鼠类线虫寄生虫毛首鞭形线虫感染并不需要黏膜肥大细胞反应。
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B cells and antibodies are required for resistance to the parasitic gastrointestinal nematode Trichuris muris.抵抗寄生性胃肠线虫毛首鞭形线虫需要B细胞和抗体。
Infect Immun. 2001 Jun;69(6):3860-8. doi: 10.1128/IAI.69.6.3860-3868.2001.

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本文引用的文献

1
Cytokine-mediated regulation of chronic intestinal helminth infection.细胞因子介导的慢性肠道蠕虫感染调节
J Exp Med. 1994 Jan 1;179(1):347-51. doi: 10.1084/jem.179.1.347.
2
IFN inhibits inflammatory responses and protective immunity in mice infected with the nematode parasite, Nippostrongylus brasiliensis.干扰素会抑制感染了巴西日圆线虫这种线虫寄生虫的小鼠的炎症反应和保护性免疫。
J Immunol. 1993 Dec 15;151(12):7086-94.
3
Th2 cells: help for helminths.辅助性T细胞2（Th2细胞）：助力对抗蠕虫感染
J Exp Med. 1994 May 1;179(5):1405-7. doi: 10.1084/jem.179.5.1405.
4
Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites.白细胞介素12对感染肠道线虫寄生虫小鼠免疫反应和宿主保护的影响。
J Exp Med. 1994 May 1;179(5):1563-72. doi: 10.1084/jem.179.5.1563.
5
Correlations between worm burden and markers of Th1 and Th2 cell subset induction in an inbred strain of mouse infected with Trichuris muris.感染毛首鞭形线虫的近交系小鼠中虫负荷与Th1和Th2细胞亚群诱导标志物之间的相关性。
Parasite Immunol. 1993 Oct;15(10):595-600. doi: 10.1111/pim.1993.15.10.595.
6
Immunity in humans to Necator americanus: IgE, parasite weight and fecundity.人类对美洲板口线虫的免疫：免疫球蛋白E、寄生虫重量和繁殖力。
Parasite Immunol. 1995 Feb;17(2):71-5. doi: 10.1111/j.1365-3024.1995.tb00968.x.
7
IL-4 treatment can cure established gastrointestinal nematode infections in immunocompetent and immunodeficient mice.白细胞介素-4治疗可治愈免疫功能正常和免疫缺陷小鼠已有的胃肠道线虫感染。
J Immunol. 1995 May 1;154(9):4675-84.
8
The use of host strain variation to assess the significance of mucosal mast cells in the spontaneous cure response of mice to the nematode Trichuris muris.利用宿主菌株变异来评估黏膜肥大细胞在小鼠对线虫毛首鞭形线虫自发治愈反应中的重要性。
Int Arch Allergy Appl Immunol. 1982;67(4):302-5. doi: 10.1159/000233037.
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Acquired immunity to Trichuris muris in the albino laboratory mouse.白化实验小鼠对鼠鞭虫的获得性免疫
Parasitology. 1967 Aug;57(3):515-24. doi: 10.1017/s0031182000072395.
10
The effects of H-2 and non-H-2 genes on the expulsion of the nematode Trichuris muris from inbred and congenic mice.H-2和非H-2基因对近交系和同源近交系小鼠体内线虫毛首鞭形线虫排出的影响。
Parasitology. 1988 Jun;96 ( Pt 3):543-50. doi: 10.1017/s0031182000080173.

抗肠道线虫寄生虫毛首鞭形线虫的抗体非依赖效应机制

Antibody-independent effector mechanisms in resistance to the intestinal nematode parasite Trichuris muris.

作者信息

Else K J, Grencis R K

机构信息

School of Biological Sciences, University of Manchester, United Kingdom.

出版信息

Infect Immun. 1996 Aug;64(8):2950-4. doi: 10.1128/iai.64.8.2950-2954.1996.

DOI:10.1128/iai.64.8.2950-2954.1996
PMID:8757819
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC174173/
Abstract

The development of a strong Th2-type immune response is essential in resistance to the intestinal nematode parasite Trichuris muris. Although the underlying cell-regulatory mechanisms important in protective immunity are well defined, the actual Th2-controlled effector mechanisms culminating in worm expulsion are uncharacterized. Using methodology involving the selective reconstitution of severe combined immunodeficiency mice with highly pure populations of CD4+ T cells from immune BALB/c donors, we show here that antibody is not an essential component in resistance to T. muris. Thus, CD4+ T cells purified from BALB/c donor mice at a time point when Th2 cells are in dominance (days 19 to 21 postinfection) confer resistance to infection on recipient severe combined immunodeficiency mice in the complete absence of an antibody response.

摘要

强大的Th2型免疫反应的发展对于抵抗肠道线虫寄生虫毛首鞭形线虫至关重要。尽管在保护性免疫中重要的潜在细胞调节机制已得到明确界定，但最终导致蠕虫排出的实际Th2控制的效应机制仍未得到表征。利用涉及用来自免疫BALB/c供体的高度纯化的CD4+ T细胞群体选择性重建严重联合免疫缺陷小鼠的方法，我们在此表明抗体不是抵抗毛首鞭形线虫的必需成分。因此，在Th2细胞占优势的时间点（感染后第19至21天）从BALB/c供体小鼠纯化的CD4+ T细胞在完全没有抗体反应的情况下赋予受体严重联合免疫缺陷小鼠抗感染能力。