Graves M, Griffin D E, Johnson R T, Hirsch R L, de Soriano I L, Roedenbeck S, Vaisberg A
J Virol. 1984 Feb;49(2):409-12. doi: 10.1128/JVI.49.2.409-412.1984.
Immune precipitation of 181 sera from 152 patients with natural measles was studied to determine the temporal course and frequency of antibody responses to nucleocapsid, fusion, hemagglutinin, and matrix proteins of measles virus. Large amounts of antibody to nucleocapsid protein developed in all patients by day one of the rash. Antibody to hemagglutinin and fusion proteins developed in all patients over the next 3 weeks, the former to high levels and the latter to low levels. Antibody to matrix protein developed to very low levels and was detectable in only 41% of the patients; this poor response to matrix protein was not correlated with the age of the patient or the acute neurological complications of measles.
对152例自然感染麻疹患者的181份血清进行免疫沉淀研究，以确定对麻疹病毒核衣壳、融合蛋白、血凝素和基质蛋白抗体反应的时间进程和频率。在出疹第一天，所有患者体内都产生了大量针对核衣壳蛋白的抗体。在接下来的3周内，所有患者体内都产生了针对血凝素和融合蛋白的抗体，前者达到高水平，后者达到低水平。针对基质蛋白的抗体产生水平非常低，仅在41%的患者中可检测到；对基质蛋白的这种低反应与患者年龄或麻疹急性神经并发症无关。
