Shikhman A R, Lebedev K A, Dil'man V M
Vopr Onkol. 1981;27(2):67-9.
Phenformin was shown to inhibit the rate of the Ehrlich carcinoma cell growth both in solid and ascitic forms of the tumor. The effect of phenformin on the tumor was eliminated by a diet containing high level of fats. The supernatant from the 18-hour culture of splenic cells, obtained from carcinoma-bearing mice treated by phenformin, inhibited phagocytosis of normal macrophages to a less extent compared with tumor-bearing mice which were not given phenformin. A peritoneal exudate from these mice was less effective in suppressing normal macrophages adhesiveness compared with untreated tumor-bearing mice.
苯乙双胍被证明能抑制艾氏腹水癌实体瘤和腹水瘤的癌细胞生长速度。高脂肪饮食可消除苯乙双胍对肿瘤的影响。与未给予苯乙双胍的荷瘤小鼠相比，从接受苯乙双胍治疗的荷癌小鼠脾脏细胞18小时培养物中获得的上清液对正常巨噬细胞吞噬作用的抑制程度较小。与未治疗的荷瘤小鼠相比，这些小鼠的腹腔渗出液在抑制正常巨噬细胞黏附方面效果较差。
