Aminoff D, Anderson J, Dabich L, Gathmann W D
Am J Hematol. 1980;9(4):381-9. doi: 10.1002/ajh.2830090405.
The sialic acid content of erythrocytes from healthy individuals of different blood types and of patients with known hematological disorders has been determined. The sialic acid was completely released enzymatically with sialidase and quantitated by the thiobarbituric acid method. The sialic acid content of erythrocytes was constant irrespective of ABO blood type, or anticoagulant used; viz, 0.85-0.92 mumoles/ml of packed erythrocytes or 46-53 X 10(6) sialyl residues per cell. Deviations from these normal values were obtained with erythrocytes from patients with a variety of hematological disorders. Patients with the following disorders have significantly (P less than 0.01) lower sialic acid values compared to erythrocytes from healthy individuals (given in the order of decreasing sialic acid content): sickle cell anemia, acute lymphocytic leukemia, chronic lymphocytic leukemia, acute myelomonocytic leukemia, non-Hodgkin lymphocytic lymphoma, chronic granulocytic leukemia, acute myelocytic leukemia, leukemia, and Hodgkin disease.
已测定了不同血型健康个体以及患有已知血液系统疾病患者红细胞中的唾液酸含量。唾液酸通过唾液酸酶酶促完全释放，并采用硫代巴比妥酸法进行定量。红细胞中的唾液酸含量是恒定的，与ABO血型或所用抗凝剂无关；即每毫升压积红细胞含0.85 - 0.92微摩尔，或每个细胞含46 - 53×10⁶个唾液酸残基。患有各种血液系统疾病患者的红细胞与这些正常值存在偏差。与健康个体的红细胞相比（按唾液酸含量递减顺序列出），患有以下疾病的患者唾液酸值显著降低（P < 0.01）：镰状细胞贫血、急性淋巴细胞白血病、慢性淋巴细胞白血病、急性粒单核细胞白血病、非霍奇金淋巴细胞淋巴瘤、慢性粒细胞白血病、急性髓细胞白血病、白血病和霍奇金病。
