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从嗜肺军团菌中分离出的一种高分子量抗原的超微结构定位及保护活性

Ultrastructural localization and protective activity of a high-molecular-weight antigen isolated from Legionella pneumophila.

作者信息

Elliott J A, Johnson W, Helms C M

出版信息

Infect Immun. 1981 Feb;31(2):822-4. doi: 10.1128/iai.31.2.822-824.1981.

DOI:10.1128/iai.31.2.822-824.1981
PMID:7216476
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC351383/
Abstract

Immunoperoxidase labeling showed that the F-1 antigen of Legionella pneumophila is located on the bacterial cell surface. Protection against lethal intraperitoneal challenge with serogroup 1 L. pneumophila was induced in guinea pigs by heat-killed cells and F-1 antigen from serogroup 1, but not by heat-killed cells or F-1 antigens from serogroup 2, 3, or 4.

摘要

免疫过氧化物酶标记显示，嗜肺军团菌的F-1抗原位于细菌细胞表面。用血清1型嗜肺军团菌的热灭活细胞和F-1抗原可诱导豚鼠对血清1型嗜肺军团菌致死性腹腔攻击产生保护作用，但血清2、3或4型的热灭活细胞或F-1抗原则不能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ce8/351383/5e9d3380cae7/iai00166-0315-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ce8/351383/5e9d3380cae7/iai00166-0315-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ce8/351383/5e9d3380cae7/iai00166-0315-a.jpg

相似文献

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Ultrastructural localization and protective activity of a high-molecular-weight antigen isolated from Legionella pneumophila.从嗜肺军团菌中分离出的一种高分子量抗原的超微结构定位及保护活性
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引用本文的文献

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本文引用的文献

1
Legionella pneumophila serogroup six: isolation from cases of legionellosis, identification by immunofluorescence staining, and immunological response to infection.嗜肺军团菌血清群6：从军团病病例中分离、通过免疫荧光染色进行鉴定以及对感染的免疫反应
J Clin Microbiol. 1980 Sep;12(3):395-401. doi: 10.1128/jcm.12.3.395-401.1980.
2
Identification of a cytotoxin produced by Legionella pneumophila.嗜肺军团菌产生的一种细胞毒素的鉴定。
Infect Immun. 1980 Jul;29(1):271-4. doi: 10.1128/iai.29.1.271-274.1980.
3
Proteolytic action of Legionella pneumophila on human serum proteins.
Infect Immun. 1983 Mar;39(3):1428-40. doi: 10.1128/iai.39.3.1428-1440.1983.
4
Immunological and biochemical relationships among flagella isolated from Legionella pneumophila serogroups 1, 2, and 3.从嗜肺军团菌血清型1、2和3分离出的鞭毛之间的免疫学和生化关系。
Infect Immun. 1981 Aug;33(2):602-10. doi: 10.1128/iai.33.2.602-610.1981.
5
Legionella pneumophila-induced suppression of macrophage spreading in vitro.嗜肺军团菌在体外诱导巨噬细胞铺展受抑制。
Infect Immun. 1983 Oct;42(1):421-3. doi: 10.1128/iai.42.1.421-423.1983.
6
Lymphoid cell blastogenesis as an in vitro indicator of cellular immunity to Legionella pneumophila antigens.淋巴细胞母细胞生成作为对嗜肺军团菌抗原细胞免疫的体外指标。
J Clin Microbiol. 1984 Jun;19(6):834-7. doi: 10.1128/jcm.19.6.834-837.1984.
7
Vaccination against Legionella pneumophila: serum antibody correlates with protection induced by heat-killed or acetone-killed cells against intraperitoneal but not aerosol infection in guinea pigs.嗜肺军团菌疫苗接种：血清抗体与热灭活或丙酮灭活的细胞诱导的针对豚鼠腹腔感染而非气溶胶感染的保护作用相关。
Infect Immun. 1984 Sep;45(3):685-91. doi: 10.1128/iai.45.3.685-691.1984.
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Infect Immun. 1983 Mar;39(3):1441-56. doi: 10.1128/iai.39.3.1441-1456.1983.
9
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Infect Immun. 1984 Jan;43(1):314-9. doi: 10.1128/iai.43.1.314-319.1984.
10
Factors influencing the reactivity of Legionella antigens in immunofluorescence tests.免疫荧光试验中影响军团菌抗原反应性的因素。
J Clin Microbiol. 1983 May;17(5):909-17. doi: 10.1128/jcm.17.5.909-917.1983.
嗜肺军团菌对人血清蛋白的蛋白水解作用。
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4
A high molecular weight antigen in Legionnaires' disease bacterium: isolation and partial characterization.
Ann Intern Med. 1979 Apr;90(4):638-41. doi: 10.7326/0003-4819-90-4-638.
5
The cell envelope of the Legionnaires' disease bacterium. Morphologic and biochemical characteristics.
Ann Intern Med. 1979 Apr;90(4):628-30. doi: 10.7326/0003-4819-90-4-628.
6
Detection of antibodies to legionnaires disease organism by microagglutination and micro-enzyme-linked immunosorbent assay tests.通过微量凝集试验和微量酶联免疫吸附测定检测军团菌病病原体抗体。
J Clin Microbiol. 1978 Apr;7(4):327-31. doi: 10.1128/jcm.7.4.327-331.1978.
7
Legionnaires' disease: antigenic peculiarities, strain differences, and antibiotic sensitivities of the agent.
J Infect Dis. 1978 Aug;138(2):260-4. doi: 10.1093/infdis/138.2.260.
8
Legionnaires' disease: isolation of a bacterium and demonstration of its role in other respiratory disease.军团病：一种细菌的分离及其在其他呼吸道疾病中的作用证明
N Engl J Med. 1977 Dec 1;297(22):1197-203. doi: 10.1056/NEJM197712012972202.
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Serospecificity and opsonic activity of antisera to Legionella pneumophila.抗嗜肺军团菌血清的血清特异性及调理活性
Infect Immun. 1979 Nov;26(2):698-704. doi: 10.1128/iai.26.2.698-704.1979.
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Four serogroups of Legionnaires' disease bacteria defined by direct immunofluorescence.通过直接免疫荧光法确定的军团病杆菌的四个血清群。
Ann Intern Med. 1979 Apr;90(4):621-4. doi: 10.7326/0003-4819-90-4-621.