Whitehead L W, Ashikaga T, Vacek P
Am Ind Hyg Assoc J. 1981 Mar;42(3):178-86. doi: 10.1080/15298668191419541.
Wood dusts may have substantial health impacts beyond those of nuisance dust. This project reports results linking pulmonary function changes with exposure to maple and pine dust. A cross-sectional survey of 1157 woodworkers was conducted in 1978 in accordance with NHLBI standards for respiratory epidemiologic surveys. Area dust levels were determined, permitting definition of groups exposed to estimated high, medium or low cumulative levels of dry hardwood or softwood dust. Prevalence of reduced (lower fifth percentile of normal) pulmonary function was ascertained, using prediction equations, for Forced Vital Capacity (FVC), Forced Expiratory Volume in 1 second (FEV1), FEV1/FVC and Maximal Mid-expiratory Flow Rate (MMEFR). Relationships between pulmonary impairment and dust exposure were examined, adjusting for smoking status by means of the log odds ratio method. The results support an association between dry hardwood or softwood dust exposure and reduced pulmonary flow rates. The odds ratios for reduced pulmonary function, comparing low and high hardwood (maple) dust exposure, were 3.12 for FEV1/FVC and 2.14 for MMEFR. Comparing low and medium hardwood exposure, the odds ratios were 2.61 for FEV1/FVC and MMEFR. Comparison of low and high softwood (pine) dust exposure yielded odds ratios of 4.03 for FEV1/FVC and 2.45 for MMEFR. The ratios noted are significant at p less than .05.
木尘可能会产生除烦扰性粉尘之外的重大健康影响。本项目报告了将肺功能变化与枫木和松木粉尘暴露联系起来的结果。1978年，按照美国国立心肺血液研究所（NHLBI）呼吸流行病学调查标准，对1157名木工进行了横断面调查。测定了工作区域的粉尘水平，从而能够界定暴露于估计的高、中或低累积水平干硬木或软木粉尘的人群组。使用预测方程确定了用力肺活量（FVC）、一秒用力呼气量（FEV1）、FEV1/FVC和最大呼气中期流速（MMEFR）肺功能降低（低于正常范围的第五百分位数）的患病率。通过对数比值比方法对吸烟状况进行校正后，研究了肺功能损害与粉尘暴露之间的关系。结果支持干硬木或软木粉尘暴露与肺流速降低之间存在关联。比较低和高硬木（枫木）粉尘暴露时，肺功能降低的比值比，FEV1/FVC为3.12，MMEFR为2.14。比较低和中硬木暴露时，FEV1/FVC和MMEFR的比值比均为2.61。比较低和高软木（松木）粉尘暴露时，FEV1/FVC的比值比为4.03，MMEFR为2.45。所提及的比值在p小于0.05时具有显著性。
