Cucuianu M, Zdrenghea D, Pop M, Opincaru A
Clin Chim Acta. 1976 Sep 20;71(3):419-27. doi: 10.1016/0009-8981(76)90093-0.
Both gamma-glutamyltransferase (gammaGT) and pseudocholinesterase (PCE) were found to be increased in hypertriglyceridemic subjects. High values of gammaGT were noted in alcoholic subjects and especially in those with either increased serum triglyceride or alanine aminotransferase higher than 16 mU/ml, while PCE was not significantly changed in alcoholic subjects. Although both enzymes were strongly correlated with the logarithm of serum triglyceride and the prebeta electrophoretic fraction, there were striking differences concerning their behavior in various hypertriglyceridemic subjects. PCE activity was high even in moderate hypertriglyceridemias but its correlation with serum triglyceride had a tendency to flatten with increasing concentration of triglyceride. However, increase of gammaGT was rather characteristic for gross hypetriglyceridemia. Short-term, triglyceride-lowering therapy was accompanied by a tendency to normalization of gammaGT, while PCE values were not influenced. An attempt was made to interpret these changes of serum-enzyme activity in hypertriglyceridemia in connection with mechanisms of lipoprotein synthesis and with the pathogeny of hyperlipemic conditions.
在高甘油三酯血症患者中发现γ-谷氨酰转移酶（γGT）和假性胆碱酯酶（PCE）均升高。在酒精性患者中γGT值较高，尤其是那些血清甘油三酯升高或丙氨酸转氨酶高于16 mU/ml的患者，而酒精性患者的PCE无明显变化。尽管这两种酶均与血清甘油三酯的对数和前β电泳分数密切相关，但在不同的高甘油三酯血症患者中它们的表现存在显著差异。即使在中度高甘油三酯血症中PCE活性也较高，但其与血清甘油三酯的相关性随甘油三酯浓度升高有趋于平缓的趋势。然而，γGT升高是严重高甘油三酯血症的相当典型的特征。短期的降甘油三酯治疗伴随着γGT趋于正常化的趋势，而PCE值不受影响。人们试图结合脂蛋白合成机制和高脂血症的发病机制来解释高甘油三酯血症中血清酶活性的这些变化。
