Thelen P, Burke V, Gracey M
J Med Microbiol. 1978 Nov;11(4):463-70. doi: 10.1099/00222615-11-4-463.
Culture filtrates of micro-organisms isolated from the upper intestinal secretions of malnourished children and grown in pure culture were shown to impair the intestinal absorption of water and electrolytes in live rats. Decreased net movement out of the intestinal lumen, or actual secretion of water, sodium or potassium into the intestinal lumen, was found with culture filtrates of single isolates of Staphylococcus epidermidis, Escherichia coli 055, Escherichia coli B7A, Shigella sonnei, Klebsiella pneumoniae, Candida albicans and Candida tropicalis. These organisms have been found to contaminate upper intestinal secretions in malnourished children and it is suggested that the effects observed in these experiments might be relevant to the production of the diarrhoea that is a dominant clinical feature of childhood malnutrition.
从营养不良儿童的上肠道分泌物中分离出并在纯培养物中生长的微生物培养滤液，被证明会损害活体大鼠肠道对水和电解质的吸收。发现表皮葡萄球菌、大肠杆菌O55、大肠杆菌B7A、宋内志贺菌、肺炎克雷伯菌、白色念珠菌和热带念珠菌的单一分离株的培养滤液会导致肠腔内净流出减少，或水、钠或钾实际分泌到肠腔内。已发现这些微生物会污染营养不良儿童的上肠道分泌物，有人认为这些实验中观察到的影响可能与腹泻的产生有关，腹泻是儿童营养不良的主要临床特征。
