Vesikari T, Janas M, Grönroos P, Tuppurainen N, Renlund M, Kero P, Koivisto M, Kunnas M, Heinonen K, Nyman R
Arch Dis Child. 1985 Jun;60(6):542-6. doi: 10.1136/adc.60.6.542.
A total of 410 proved cases of neonatal septicaemia from seven Finnish hospitals seen between 1976 and 1980 were reviewed. The annual incidence of neonatal septicaemia was 3 per 1000 births, and overall mortality was 23%. Onset was early in most patients. Symptoms of septicaemia occurred within the first 24 hours of life in 44% and within the first week of life in 90%. In the very early onset disease (within 24 hours) mortality was 30%, compared with 17% in all other cases. Group B streptococcus was the leading cause in very early onset disease (52%) but mortality from infection with this organism was similar to that in other very early onset cases. It is concluded that very early onset neonatal septicaemia, probably of intrauterine origin and caused by group B streptococcus in one half of the cases, constitutes the major form of neonatal septicaemia in Finland and should receive the highest priority in preventive measures.
对1976年至1980年间芬兰七家医院收治的410例确诊新生儿败血症病例进行了回顾性研究。新生儿败血症的年发病率为每1000例出生3例，总体死亡率为23%。大多数患者起病较早。44%的败血症症状出现在出生后的头24小时内，90%出现在出生后的第一周内。在极早期发病（24小时内）的疾病中，死亡率为30%，而在所有其他病例中为17%。B组链球菌是极早期发病疾病的主要病因（52%），但该菌感染导致的死亡率与其他极早期发病病例相似。结论是，极早期发病的新生儿败血症，可能起源于宫内，半数病例由B组链球菌引起，是芬兰新生儿败血症的主要形式，在预防措施中应给予最高优先级。
