Ohata M, Sundaram U, Fredericks W R, London E D, Rapoport S I
Brain. 1981 Jun;104(2):319-32. doi: 10.1093/brain/104.2.319.
Regional cerebral blood flow (rCBF) in the conscious Fischer-344 rat was measured in 14 brain regions at 5 different ages. rCBF increased significantly (P less than 0.05) in most anterior brain regions between 1 and 3 months of age, but not in phylogenetically more primitive regions from the mid- and hindbrain that may have matured prior to 1 month of age. rCBF tended to increase or remain constant between 3 and 12 months, and rose significantly in the frontal lobe. Between 12 and 24 months of age, rCBF declined by an average of 17 per cent and fell significantly in 5 brain regions, mainly from the posterior brain, and in some, possibly in relation to partial functional deafferentation. There were no statistically significant changes in rCBF between 24 and 34 months of age. rCBF and local cerebral glucose utilization (LCGU) do not follow identical time courses during development and maturation of the rat brain. A fall in LCGU between 3 and 12 months of age, when rCBF remains constant or tends to rise, may reflect increased sensitivity of the cerebrovascular bed to metabolic factors which regulate cerebral blood flow.
在5个不同年龄段对清醒的Fischer-344大鼠的14个脑区进行了局部脑血流量（rCBF）测量。在1至3月龄期间，大多数前脑区域的rCBF显著增加（P小于0.05），但中脑和后脑在系统发育上更原始的区域（可能在1月龄前已经成熟）则没有增加。在3至12月龄之间，rCBF趋于增加或保持稳定，且额叶的rCBF显著上升。在12至24月龄之间，rCBF平均下降了17%，5个脑区（主要来自后脑）的rCBF显著下降，部分可能与部分功能性传入神经阻滞有关。在24至34月龄之间，rCBF没有统计学上的显著变化。在大鼠脑发育和成熟过程中，rCBF和局部脑葡萄糖利用（LCGU）的时间进程并不相同。在3至12月龄之间，当rCBF保持稳定或趋于上升时，LCGU下降，这可能反映了脑血管床对调节脑血流量的代谢因子的敏感性增加。
