Kimura H, Kanno M, Takamura H, Arakawa H, Maeda K, Uogishi M, Sodani H, Kawashima A
Department of Gastroenterology, Keiju Hospital, Ishikawa, Japan.
J Gastroenterol. 1995 Feb;30(1):108-12. doi: 10.1007/BF01211384.
This paper describes an unusual case of an 80-year-old man followed up for multifocal gastric cancers. There were three separate polypoid carcinomas and one adenomatous polyp with no sign of malignancy. We measured the DNA content of the gastric cancer and adenomatous cells obtained from endoscopically biopsied specimens. The adenomatous polyp and one of the cancerous lesions showed DNA diploidy. The other two cancerous lesions showed DNA aneuploidy, with different DNA index (DI) values (1.12 and 1.64, respectively). It is considered that the three cancers arose from different stem lines. However, an operation was not performed because the patient refused gastrectomy, and therefore only conservative follow up has been continued. Presentation of this case is followed by a detailed discussion focusing on the possible development of carcinoma in gastric adenomatous polyps in view of the data from the literature.
本文描述了一例不同寻常的病例，一名80岁男性因多灶性胃癌接受随访。有三个独立的息肉样癌和一个无恶性迹象的腺瘤性息肉。我们测量了通过内镜活检标本获得的胃癌和腺瘤细胞的DNA含量。腺瘤性息肉和其中一个癌性病变显示为DNA二倍体。另外两个癌性病变显示为DNA非整倍体，具有不同的DNA指数（DI）值（分别为1.12和1.64）。据认为这三种癌症起源于不同的干细胞系。然而，由于患者拒绝胃切除术，未进行手术，因此仅继续进行保守随访。本文在介绍该病例后，将根据文献数据，围绕胃腺瘤性息肉中可能发生癌变的情况展开详细讨论。
