Coppola A, Chordia P L, De Rosa J
Ann Clin Lab Sci. 1981 Mar-Apr;11(2):152-7.
Gram negative bacteria were seen in the peripheral blood and within the neutrophils of a patient with bacteremic shock secondary to Pseudomonas aeruginosa infection. By electron microscopy, bacteria were present either in vacuoles or in the cytoplasm of neutrophils. When seen in the cytoplasm, they were surrounded by amorphous material which most probably represented fused lysosomal granules. In both cases, the microorganisms appeared morphologically normal. The presumption is that there was a pre-existing defect of neutrophilic lysosomal formation or function. These findings indicate the importance of studying neutrophil morphology and function in patients with persistent infections.
在一名因铜绿假单胞菌感染继发败血性休克的患者的外周血和中性粒细胞内发现了革兰氏阴性菌。通过电子显微镜观察，细菌存在于中性粒细胞的液泡或细胞质中。当出现在细胞质中时，它们被无定形物质包围，这些无定形物质很可能代表融合的溶酶体颗粒。在这两种情况下，微生物在形态上看起来都是正常的。推测是中性粒细胞溶酶体形成或功能预先存在缺陷。这些发现表明研究持续性感染患者中性粒细胞形态和功能的重要性。
