Shulman S, Harlin B, Davis P
Urology. 1978 Nov;12(5):582-6. doi: 10.1016/0090-4295(78)90480-6.
A history is presented of a couple suffering from long-standing infertility, which on laboratory investigation was found to be immunologic infertility, as expressed in the male partner. This case of male infertility was diagnosed by findings of sperm antibody in both the serum and the seminal plasma of the man, using both the Kibrick and the F-D sperm agglutination test methods. A new effort at treatment, by means of attempted immunosuppression, was proposed and applied, using corticosteroid medication. The special feature of this treatment involved a high dosage (96 mg. per day of methylprednisolone) for a short period (seven days). Laboratory studies revealed that the antibody levels, in both his serum and seminal plasma, did fall considerably. The wife became pregnant in the subsequent cycle. It is proposed that such diagnostic and treatment efforts be tried in other cases of male immunologic infertility.
本文介绍了一对长期不孕的夫妇，经实验室检查发现是免疫性不孕，表现为男性伴侣的问题。该男性不育病例是通过使用基布里克（Kibrick）和F-D精子凝集试验方法，在男性的血清和精浆中均发现精子抗体而确诊的。提出并应用了一种新的治疗方法，即尝试通过使用皮质类固醇药物进行免疫抑制。这种治疗的特殊之处在于短期内（七天）使用高剂量（每天96毫克甲泼尼龙）。实验室研究表明，他的血清和精浆中的抗体水平均大幅下降。妻子在随后的周期中怀孕。建议在其他男性免疫性不育病例中尝试这种诊断和治疗方法。
