Bernhardt-Smigielska J, Toczko K
Acta Biochim Pol. 1980;27(3-4):221-31.
The effect of cycloheximide on protein and DNA synthesis and on the structure of chromatin was studied. Changes in the rate and extent of DNA synthesis in response to cycloheximide were highly variable in contrast to the extremely rapid and reproducible inhibition of protein synthesis. No differences in the rate of the release of acid-soluble products by nucleases and in the nature of the nucleoprotein particles were found in chromatin from plasmodia treated and non-treated with cycloheximide. It is concluded that, in Physarum polycephalum, unlike in higher animals, chromatin from the antibiotic-treated plasmodia is structurally indiscernible by the methods applied from normal chromatin.
研究了放线菌酮对蛋白质和DNA合成以及染色质结构的影响。与蛋白质合成受到的极其快速且可重复的抑制相反，放线菌酮对DNA合成速率和程度的影响变化很大。在用放线菌酮处理和未处理的疟原虫染色质中，未发现核酸酶释放酸溶性产物的速率以及核蛋白颗粒性质存在差异。得出的结论是，在多头绒泡菌中，与高等动物不同，用抗生素处理过的疟原虫的染色质在用所应用的方法与正常染色质相比在结构上难以区分。
