一种牛疱疹病毒1亚单位疫苗未能预防犊牛实验性呼吸道疾病。
Failure of a subunit bovine herpesvirus 1 vaccine to protect against experimental respiratory disease in calves.
作者信息
Darcel C L, Jericho K W
出版信息
Can J Comp Med. 1981 Jan;45(1):87-91.
In two experiments in which 31 calves were used, a bovine herpesvirus 1 subunit vaccine previously shown to elicit a strong immunological response in adult cattle failed to do so in younger animals and failed to protect against pneumonia caused by sequential exposure to virulent bovine herpesvirus 1 and Pasteurella haemolytica aerosols. One of the experimental groups had been previously inoculated with a live commercial vaccine but even this failed to elicit a strong immunological response. These results indicate that the calves were in a refractory state when immunized and may explain why similar vaccine failures occur in the field.
在使用31头小牛的两项实验中，一种先前已证明能在成年牛中引发强烈免疫反应的牛疱疹病毒1亚单位疫苗，在年幼动物中却未能引发这种反应，并且在小牛连续接触强毒牛疱疹病毒1和气雾型溶血巴斯德氏菌后，无法预防由此引起的肺炎。其中一个实验组先前已接种过一种市售活疫苗，但即便如此也未能引发强烈的免疫反应。这些结果表明，小牛在免疫时处于不应答状态，这或许可以解释为何在实际应用中会出现类似的疫苗接种失败情况。
Zotero 插件