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1
Failure of a subunit bovine herpesvirus 1 vaccine to protect against experimental respiratory disease in calves.一种牛疱疹病毒1亚单位疫苗未能预防犊牛实验性呼吸道疾病。
Can J Comp Med. 1981 Jan;45(1):87-91.
2
Bovine herpesvirus-1 vaccination against experimental bovine herpesvirus-1 and Pasteurella haemolytica respiratory tract infection: onset of protection.针对实验性牛疱疹病毒-1和溶血巴斯德氏菌呼吸道感染的牛疱疹病毒-1疫苗接种：保护作用的开始
Am J Vet Res. 1982 Oct;43(10):1776-80.
3
Aerosol vaccination of calves with pasteurella haemolytica against experimental respiratory disease.用溶血巴斯德氏菌对犊牛进行气溶胶接种以预防实验性呼吸道疾病。
Can J Comp Med. 1982 Jul;46(3):287-92.
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The effect of dose, route and virulence of bovine herpesvirus 1 vaccine on experimental respiratory disease in cattle.牛疱疹病毒1型疫苗的剂量、接种途径和毒力对牛实验性呼吸道疾病的影响。
Can J Comp Med. 1983 Apr;47(2):133-9.
5
Experimental bovine pneumonic pasteurellosis. I. Prevention of the disease.实验性牛肺炎巴氏杆菌病。I. 疾病的预防
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Serologic response to Mannheimia haemolytica in calves concurrently inoculated with inactivated or modified-live preparations of M. haemolytica and viral combination vaccines containing modified-live bovine herpesvirus type 1.同时接种溶血曼氏杆菌灭活或减毒活制剂以及含1型牛疱疹病毒减毒活疫苗的病毒联合疫苗的犊牛对溶血曼氏杆菌的血清学反应。
Am J Vet Res. 2011 Nov;72(11):1541-9. doi: 10.2460/ajvr.72.11.1541.
7
Experimental infectious respiratory disease in groups of calves: lobar distribution, variance, and sample-size requirements for vaccine evaluation.犊牛群体中的实验性传染性呼吸道疾病：叶状分布、变异性及疫苗评估的样本量要求
Can J Vet Res. 2004 Apr;68(2):118-27.
8
Prevention of experimental bovine pneumonic pasteurellosis with an extract of Pasteurella haemolytica.用溶血巴氏杆菌提取物预防实验性牛肺炎巴氏杆菌病
Can J Comp Med. 1983 Jul;47(3):250-6.
9
Experimental bovine pneumonic pasteurellosis. II. Genesis and prevention.实验性牛肺炎巴氏杆菌病。II. 发病机理与预防
Can J Comp Med. 1979 Jul;43(3):272-9.
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Efficacy of a streptomycin-dependent, live Pasteurella haemolytica vaccine against challenge exposure to Pasteurella haemolytica in cattle.一种依赖链霉素的溶血性巴氏杆菌活疫苗对牛经溶血性巴氏杆菌攻击暴露后的效力。
Am J Vet Res. 1987 Apr;48(4):637-42.

引用本文的文献

1
Experimental infectious respiratory disease in groups of calves: lobar distribution, variance, and sample-size requirements for vaccine evaluation.犊牛群体中的实验性传染性呼吸道疾病：叶状分布、变异性及疫苗评估的样本量要求
Can J Vet Res. 2004 Apr;68(2):118-27.
2
Pneumonia in calves produced with aerosols of Pasteurella multocida alone and in combination with bovine herpesvirus 1.单独使用多杀性巴氏杆菌气雾剂以及与牛疱疹病毒1联合使用产生的犊牛肺炎。
Can J Comp Med. 1985 Apr;49(2):138-44.

本文引用的文献

1
Factors associated with mortality in feedlot cattle: the Bruce County Beef Cattle Project.饲养场肉牛的死亡相关因素：布鲁斯县肉牛项目
Can J Comp Med. 1980 Jan;44(1):1-10.
2
Evaluation of experimental subunit vaccines for infectious bovine rhinotracheitis.牛传染性鼻气管炎实验性亚单位疫苗的评估
Am J Vet Res. 1980 Mar;41(3):383-90.
3
Infectious bovine rhinotracheitis (IBR) abortion observations on incidence in vaccinated and non-vaccinated and exposed cattle.关于接种疫苗和未接种疫苗且暴露于感染源的牛群中传染性牛鼻气管炎（IBR）流产发生率的观察
Cornell Vet. 1973 Jul;63(3):383-9.
4
A field trial to evaluate an intranasal infectious bovine rhinotracheitis vaccine.一项评估鼻内接种传染性牛鼻气管炎疫苗的田间试验。
Can Vet J. 1974 Nov;15(11):327-30.
5
A mycoplasma isolated from cattle with infectious bovine keratoconjunctivitis.从患有传染性牛角膜结膜炎的牛身上分离出的一种支原体。
Can J Comp Med. 1969 Oct;33(4):275-9.
6
Experimental bovine pneumonic pasteurellosis. II. Genesis and prevention.实验性牛肺炎巴氏杆菌病。II. 发病机理与预防
Can J Comp Med. 1979 Jul;43(3):272-9.
7
Immunogenicity of subviral herpes simplex virus preparations. I. Formation of neutralizing antibodies in different animal species after administration of herpes simplex virus solubilized antigens.亚病毒单纯疱疹病毒制剂的免疫原性。I. 给予单纯疱疹病毒溶解抗原后不同动物物种中中和抗体的形成。
Arch Virol. 1979;61(1-2):141-7. doi: 10.1007/BF01320598.
8
Immune response of cattle to antigens obtained from bovine herpesvirus 1-infected tissue culture.牛对从感染牛疱疹病毒1的组织培养物中获得的抗原的免疫反应。
Can J Comp Med. 1979 Jul;43(3):288-94.
9
Mechanisms of recovery from Herpesvirus infections -a review.疱疹病毒感染的恢复机制——综述
Can J Comp Med. 1978 Oct;42(4):414-27.
10
Pneumonia in calves produced with aerosols of bovine herpesvirus 1 and Pasteurella haemolytica.用牛疱疹病毒1和气肿疽梭菌气雾剂诱发犊牛肺炎。 （注：你原文中的“Pasteurella haemolytica”有误，应该是“Clostridium chauvoei”，按照正确的翻译如上，若按你提供的错误原文翻译为“溶血巴斯德氏菌”，这与引发犊牛肺炎的实际病菌不符，所以我推测你可能有笔误，故给出正确的翻译参考。）
Can J Comp Med. 1978 Jul;42(3):269-77.

一种牛疱疹病毒1亚单位疫苗未能预防犊牛实验性呼吸道疾病。

Failure of a subunit bovine herpesvirus 1 vaccine to protect against experimental respiratory disease in calves.

作者信息

Darcel C L, Jericho K W

出版信息

Can J Comp Med. 1981 Jan;45(1):87-91.

PMID:7272846
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1320126/
Abstract

In two experiments in which 31 calves were used, a bovine herpesvirus 1 subunit vaccine previously shown to elicit a strong immunological response in adult cattle failed to do so in younger animals and failed to protect against pneumonia caused by sequential exposure to virulent bovine herpesvirus 1 and Pasteurella haemolytica aerosols. One of the experimental groups had been previously inoculated with a live commercial vaccine but even this failed to elicit a strong immunological response. These results indicate that the calves were in a refractory state when immunized and may explain why similar vaccine failures occur in the field.

摘要

在使用31头小牛的两项实验中，一种先前已证明能在成年牛中引发强烈免疫反应的牛疱疹病毒1亚单位疫苗，在年幼动物中却未能引发这种反应，并且在小牛连续接触强毒牛疱疹病毒1和气雾型溶血巴斯德氏菌后，无法预防由此引起的肺炎。其中一个实验组先前已接种过一种市售活疫苗，但即便如此也未能引发强烈的免疫反应。这些结果表明，小牛在免疫时处于不应答状态，这或许可以解释为何在实际应用中会出现类似的疫苗接种失败情况。