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成分和序列研究表明,A/鸭/乌克兰/1/63血凝素(Hav7)属于香港(H3)亚型。

Composition and sequence studies show that A/duck/Ukraine/1/63 haemagglutinin (Hav7) belongs to the Hong Kong (H3) subtype.

作者信息

Ward C W, Webster R G, Inglis A S, Dopheide T A

出版信息

J Gen Virol. 1981 Mar;53(Pt 1):163-8. doi: 10.1099/0022-1317-53-1-163.

Abstract

The haemagglutinin chains HA1 and HA2 from the avian influenza virus A/duck/Ukraine/1/63 (Hav7, Neq2) have been subjected to amino acid analysis and N-terminal sequencing. Automated sequenator analysis of HA1 (40 cycles), after enzymic removal of the N-terminal pyroglutamic acid blocking group, and HA2 (43 cycles) showed that the Hav7 haemagglutinin closely resembled the human Hong Kong (H3) haemagglutinins including the presence of the characteristic extended 10 residue sequence at the N-terminus of HA1. These findings, together with the amino acid compositions for both chains, demonstrate that the Hav7 haemagglutinin is structurally similar to the Hong Kong (H3) haemagglutinins.

摘要

对禽流感病毒A/鸭/乌克兰/1/63(Hav7,Neq2)的血凝素链HA1和HA2进行了氨基酸分析和N端测序。在酶法去除N端焦谷氨酸封闭基团后,对HA1(40个循环)和HA2(43个循环)进行自动测序仪分析,结果显示Hav7血凝素与人类香港(H3)血凝素非常相似,包括在HA1的N端存在特征性的10个残基延伸序列。这些发现,连同两条链的氨基酸组成,表明Hav7血凝素在结构上与香港(H3)血凝素相似。

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