香港甲型流感亚型的演变。A/鸭/乌克兰/1/63（Hav 7）血凝素与香港（H3）血凝素之间的结构关系。
Evolution of the Hong Kong influenza A sub-type. Structural relationships between the haemagglutinin from A/duck/Ukraine/1/63 (Hav 7) and the Hong Kong (H3) haemagglutinins.
作者信息
Ward C W, Dopheide T A
出版信息
Biochem J. 1981 Apr 1;195(1):337-40. doi: 10.1042/bj1950337.
Abstract
The relationship between the haemagglutinin from the influenza virus A/duck/Ukraine/1/63 (Hav 7) and the human Hong Kong variants (H3) has been investigated. Amino-acid-sequence analysis shows that the Hav 7 haemagglutinin closely resembles the 1968 human H3 haemagglutinin in structure. However, the number of amino-acid-sequence differences (23) suggest that the Hong Kong haemagglutinin gene did not come directly from A/duck/Ukraine/1/63 but from a virus derived from it by antigenic drift during the period 1963-1968.
摘要
对甲型流感病毒A/鸭/乌克兰/1/63（Hav 7）的血凝素与人类香港变种（H3）之间的关系进行了研究。氨基酸序列分析表明，Hav 7血凝素在结构上与1968年的人类H3血凝素极为相似。然而，氨基酸序列差异的数量（23个）表明，香港血凝素基因并非直接来自A/鸭/乌克兰/1/63，而是来自1963年至1968年期间由其通过抗原漂移衍生出的一种病毒。
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