H-2复合体I区中三个Ia基因座的免疫化学证据。
Immunochemical evidence for three Ia loci in the I-region of the H-2 complex.
作者信息
Delovitch T L, Murphy D B, McDevitt H O
出版信息
J Exp Med. 1977 Dec 1;146(6):1549-60. doi: 10.1084/jem.146.6.1549.
Abstract
Sequential immunoprecipitation analyses of Ia antigens were performed with 125I-labeled B10, B10.A(3R), and B10.A(5R) spleen cell lysates. The results suggest the presence of one I-region associated (Ia) locus (Ia-1) in the I-A subregion. In addition, they indicate that two Ia loci map between the I-J and S regions. One locus, Ia-5, maps in the I-E subregion. The second locus, most likely Ia-3, maps in either the I-E or I-C subregion. Taken together, the data demonstrate that at least three Ia loci in the I-region of the H-2 complex code for molecules detectable by immunoprecipitation.
摘要
用¹²⁵I标记的B10、B10.A(3R)和B10.A(5R)脾细胞裂解物进行Ia抗原的连续免疫沉淀分析。结果表明在I-A亚区存在一个I区相关（Ia）基因座（Ia-1）。此外，结果表明有两个Ia基因座定位于I-J和S区之间。一个基因座Ia-5定位于I-E亚区。第二个基因座很可能是Ia-3，定位于I-E或I-C亚区。综合来看，这些数据表明H-2复合体I区中至少有三个Ia基因座编码可通过免疫沉淀检测到的分子。
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