抗Ia血清对促有丝分裂反应的影响。III. 将伴刀豆球蛋白A反应性细胞上控制Ia决定簇表达的基因定位到H-2基因复合体的I-J亚区。
Effects of anti-Ia sera on mitogenic responses. III. Mapping the genes controlling the expression of Ia determinants on concanavalin A-reactive cells to the I-J subregion of the H-2 gene complex.
作者信息
Frelinger J A, Niederhuber J E, Shreffler D C
出版信息
J Exp Med. 1976 Oct 1;144(4):1141-6. doi: 10.1084/jem.144.4.1141.
Abstract
We have shown that the Ia determinants expressed on nylon wool-purified T lymphocytes reactive to concanavalin A (Con A) in serum-free media are coded in a single I subregion of the H-2 gene complex. This region, I-J, is defined by two pairs of intra-H-2 recombinant haplotypes: H-2t3, H-2t4 and H-2i3, H-2i5, carried by B10.HTT, B10.S(9R), B10.A(3R), AND B10.A(5R), respectively. No activity against Con A-reactive T cells has been detected in any antiserum that was produced in strain combinations which shared a common I-J region. This suggests that Ia antigens expressed on Con A-reactive T cells are restricted to the I-J subregion.
摘要
我们已经表明，在无血清培养基中对刀豆球蛋白A（Con A）有反应的经尼龙毛纯化的T淋巴细胞上表达的Ia决定簇，是由H-2基因复合体的单个I亚区编码的。这个区域，即I-J，由两对H-2内重组单倍型定义：分别由B10.HTT、B10.S(9R)、B10.A(3R)和B10.A(5R)携带的H-2t3、H-2t4以及H-2i3、H-2i5。在共享共同I-J区域的品系组合中产生的任何抗血清中，均未检测到针对Con A反应性T细胞的活性。这表明在Con A反应性T细胞上表达的Ia抗原局限于I-J亚区。
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本文引用的文献
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Tissue distribution of I region-associated antigens in the mouse.小鼠中I区相关抗原的组织分布
J Immunol. 1974 Jul;113(1):181-8.
2
A rapid method for the isolation of functional thymus-derived murine lymphocytes.一种分离功能性胸腺来源的小鼠淋巴细胞的快速方法。
Eur J Immunol. 1973 Oct;3(10):645-9. doi: 10.1002/eji.1830031011.
3
Evidence for the expression of Ia (H-2-associated) antigens on thymus-derived lymphocytes.胸腺来源淋巴细胞上Ia（与H-2相关）抗原表达的证据。
J Exp Med. 1974 Nov 1;140(5):1273-84. doi: 10.1084/jem.140.5.1273.
4
A mouse B-cell alloantigen determined by gene(s) linked to the major histocompatibility complex.一种由与主要组织相容性复合体连锁的基因所决定的小鼠B细胞同种抗原。
J Exp Med. 1973 Dec 1;138(6):1289-304. doi: 10.1084/jem.138.6.1289.
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Ly antigens: markers of T cell function on mouse spleen cells.Ly抗原：小鼠脾细胞上T细胞功能的标志物。
J Immunol. 1975 Dec;115(6):1555-7.
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Ia alloantigen(s) detected on thymocytes by use of a fluorescence-activated cell sorter.通过使用荧光激活细胞分选仪在胸腺细胞上检测到Ia同种抗原。
J Immunol. 1975 Aug;115(2):584-9.
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Separation of helper T cells from suppressor T cells expressing different Ly components. I. Polyclonal activation: suppressor and helper activities are inherent properties of distinct T-cell subclasses.从表达不同Ly成分的抑制性T细胞中分离辅助性T细胞。I. 多克隆激活：抑制活性和辅助活性是不同T细胞亚类的固有特性。
J Exp Med. 1976 Jun 1;143(6):1382-90. doi: 10.1084/jem.143.6.1382.
8
Effects of anti-Ia sera on mitogenic responses. II. Differential expression of the Ia marker on phytohemagglutinin and concanavalin A-reactive T cells.抗Ia血清对促有丝分裂反应的影响。II. 植物血凝素和刀豆球蛋白A反应性T细胞上Ia标志物的差异表达。
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9
The Fc receptor on thymus-derived lymphocytes: II. Mitogen responsiveness of T lymphocytes bearing the Fc receptor.胸腺衍生淋巴细胞上的Fc受体：II. 带有Fc受体的T淋巴细胞的丝裂原反应性。
J Exp Med. 1975 Nov 1;142(5):1041-51. doi: 10.1084/jem.142.5.1041.
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