Nemery B, Moavero N E, Brasseur L, Stănescu D C
Am Rev Respir Dis. 1981 Sep;124(3):232-8. doi: 10.1164/arrd.1981.124.3.232.
In 54 asymptomatic lifelong nonsmokers and 105 current smokers, all steelworkers 45 to 55 yr of age, we measured several lung function indexes in order to assess the significance of small airway tests, slope of phase III of the N2 single-breath washout (delta N2), and bolus closing volume and closing capacity (CC/TLC). Smokers had all mean indexes significantly different from nonsmokers, with CC/TLC and delta N2 being the most frequently impaired tests. Smokers with small airway disease (abnormal CC/TLC or delta N2) but normal forced expiratory volume in one second (FEV1) vital capacity had a significantly lower FEV1/height3 (p less than 0.001) than subjects without small airway disease. The latter had indexes similar to nonsmokers. Our data suggested that smokers with small airway disease experience a more rapid decline in their FEV1 and thus are more susceptible to long-term smoking than smokers without small airway disease. The later appear to be resistant to tobacco-induced chronic airflow obstruction.
在54名无症状的终身不吸烟者和105名现吸烟者（均为45至55岁的钢铁工人）中，我们测量了多项肺功能指标，以评估小气道测试、氮气单次呼吸洗脱第三阶段斜率（△N2）、团注闭合容积和闭合容量（CC/TLC）的意义。吸烟者的所有平均指标与不吸烟者均有显著差异，其中CC/TLC和△N2是最常受损的测试。患有小气道疾病（CC/TLC或△N2异常）但一秒用力呼气容积（FEV1）/肺活量正常的吸烟者，其FEV1/身高³显著低于无小气道疾病的受试者（p<0.001）。后者的指标与不吸烟者相似。我们的数据表明，患有小气道疾病的吸烟者其FEV1下降更快，因此比无小气道疾病的吸烟者更容易受到长期吸烟的影响。后者似乎对烟草诱导的慢性气流阻塞具有抵抗力。
