Jones K W, Singh L
Hum Genet. 1981;58(1):46-53. doi: 10.1007/BF00284148.
Satellite DNA isolated from female Elapid snakes contains nucleotide sequences which are quantitatively derived from the W sex-determining chromosome. Certain of these sequences are highly conserved in vertebrates, including mammals, where they are arranged in a sex-specific pattern in Southern blots. Sex reversed mice (Sxr) show a DNA arrangement of these sequences in conformity with their phenotypic sex, suggesting that this DNA is closely connected with the determination of sex. In situ hybridization of the snake sequences with mouse chromosomes reveals a concentration of related DNA at the proximal tip of the mouse Y chromosome. This possible nature and significance of these observations is discussed.
从雌性眼镜蛇科蛇类中分离出的卫星DNA含有核苷酸序列，这些序列在数量上源自W性染色体。其中某些序列在包括哺乳动物在内的脊椎动物中高度保守，在Southern印迹中它们以性别特异性模式排列。性反转小鼠（Sxr）显示出这些序列的DNA排列与其表型性别一致，这表明这种DNA与性别决定密切相关。将蛇的序列与小鼠染色体进行原位杂交，结果显示在小鼠Y染色体近端末端有相关DNA的聚集。本文讨论了这些观察结果可能的性质和意义。
