Urbina C, Ortiz C, Hurtado I
Int Arch Allergy Appl Immunol. 1981;66(2):158-60. doi: 10.1159/000232814.
It is believed that mice do not express cutaneous basophil hypersensitivity because they have few or no basophils. We have looked for these cells in peripheral blood smears of C3H/He, DBA/2, C57BL/6, and Balb/c mice before and after a series of foreign protein injections, a treatment known to induce basophilia. We found 0.2 and 1.5% basophils in the untreated C3H/He and DBA/2 mice and no basophils in the untreated C57BL/6 and Balb/c mice. Basophilia of 2--10% was found in the treated mice of the four strains. We noticed that the microscopic appearance of the mouse basophils differs from that in other species. These results indicate that basophils may be as frequent in mice--believed not to express cutaneous basophil hypersensitivity--as they are both in man and guinea pigs--known to express this entity. Since the mouse basophils have a distinct morphology, different from that of other species, it is possible that they may not have been noticed in routine skin preparations.
人们认为小鼠不会表现出皮肤嗜碱性粒细胞超敏反应，因为它们几乎没有或根本没有嗜碱性粒细胞。我们在给C3H/He、DBA/2、C57BL/6和Balb/c小鼠注射一系列外源蛋白之前和之后，对外周血涂片进行了观察，这种处理方法已知会诱发嗜碱性粒细胞增多。我们在未处理的C3H/He和DBA/2小鼠中发现了0.2%和1.5%的嗜碱性粒细胞，而在未处理的C57BL/6和Balb/c小鼠中未发现嗜碱性粒细胞。在这四个品系经处理的小鼠中发现了2%至10%的嗜碱性粒细胞增多。我们注意到小鼠嗜碱性粒细胞的微观外观与其他物种不同。这些结果表明，在被认为不会表现出皮肤嗜碱性粒细胞超敏反应的小鼠中，嗜碱性粒细胞可能与已知会表现出这种反应的人类和豚鼠一样常见。由于小鼠嗜碱性粒细胞具有与其他物种不同的独特形态，因此在常规皮肤标本中可能未被注意到。
