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老年人群中乙型流感的爆发。

An outbreak of influenza B in an elderly population.

作者信息

Hall W N, Goodman R A, Noble G R, Kendal A P, Steece R S

出版信息

J Infect Dis. 1981 Oct;144(4):297-302. doi: 10.1093/infdis/144.4.297.

Abstract

An outbreak of influenza B occurred in an elderly population residing in a Minnesota nursing home between April 24 and May 21, 1979 and involved 129 (35.9%) of the 359 residents. Throat swabs from 11 and 19 acutely ill residents yielded influenza B virus similar to the B/Singapore/79 strain. Fourfold or greater increases in titer of complement-fixing or hemagglutination-inhibiting antibodies were detected in paired sera from 18 of the 19 persons affected and from three of 16 unaffected residents. Three hundred thirty-three (93%) of the 359 residents had received trivalent influenza virus vaccine in November 1978. The attack rate was age-specific and increased with age (z = 2.69; P = 0.007). Increasing susceptibility to influenza B with age in the elderly has not been previously demonstrated in this infrequently studied population. Increased risk for becoming ill was also found to be statistically associated with decreasing levels of care required and residence in closed wards and temporally associated with taking meals in the facility's dining areas.

摘要

1979年4月24日至5月21日期间,明尼苏达州一家养老院的老年人群中爆发了乙型流感,359名居民中有129人(35.9%)感染。从11名和19名急性病患者的咽拭子中分离出的乙型流感病毒与B/新加坡/79毒株相似。在19名受感染人员中的18人以及16名未受感染居民中的3人的配对血清中,检测到补体结合抗体或血凝抑制抗体效价有四倍或更大幅度的升高。359名居民中有333人(93%)在1978年11月接种了三价流感病毒疫苗。发病率具有年龄特异性,且随年龄增长而升高(z = 2.69;P = 0.007)。在这个此前很少被研究的人群中,老年人对乙型流感易感性随年龄增加的情况此前尚未得到证实。还发现患病风险增加在统计学上与所需护理水平降低以及住在封闭病房有关,并且在时间上与在养老院餐厅用餐有关。

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