Tzipori S, Angus K W, Gray E W, Campbell I, Allan F
Am J Vet Res. 1981 Aug;42(8):1400-4.
Two to 5 days after oral inoculation with Cryptosporidium obtained from infected calves, 7 newborn specific-pathogen-free lambs became depressed and anorectic and developed diarrhea. Four moribund lambs were killed within 3 days after onset of illness, and the 3 other lambs died after protracted intermittent diarrhea and reduced milk intake, which lasted up to 14 days. The small and large intestines were heavily infected with Cryptosporidium, with the terminal portion of the ileum being the most severely affected. Histologic examination revealed villous atrophy, with considerable fusion and epithelial cross-bridging between villi. Lambs infected at 5 to 20 days of age had less severe clinical signs of disease, with intermittent diarrhea, reduced milk intake, and growth retardation. Lambs infected at 30 days of age became infected with the organism, but did not develop clinical signs of disease or growth retardation.
用从感染小牛获得的隐孢子虫进行口服接种后2至5天，7只新生的无特定病原体羔羊变得精神沉郁、食欲不振并出现腹泻。4只濒死羔羊在发病后3天内被处死，另外3只羔羊在持续间歇性腹泻和奶摄入量减少后死亡，这种情况持续长达14天。小肠和大肠严重感染隐孢子虫，回肠末端受影响最严重。组织学检查显示绒毛萎缩，绒毛之间有相当程度的融合和上皮交叉桥接。5至20日龄感染的羔羊疾病临床症状较轻，表现为间歇性腹泻、奶摄入量减少和生长发育迟缓。30日龄感染的羔羊感染了该病原体，但未出现疾病临床症状或生长发育迟缓。
