Pedersen-Bjergaard U, Høst U, Kelbaek H, Schifter S, Rehfeld J F, Faber J, Christensen N J
Department of Endocrinology, Herlev University Hospital, Hillerød, Denmark.
Scand J Clin Lab Invest. 1996 Oct;56(6):497-503. doi: 10.3109/00365519609088805.
In a randomized cross-over study healthy non-obese male human subjects received standardized isocaloric, isovolumetric meals consisting of either carbohydrate, protein or fat and a non-caloric control meal consisting of an equal volume of water. Peripheral venous plasma concentrations of calcitonin gene-related peptide (CGRP), substance P (SP), vasoactive intestinal peptide (VIP), and peptide YY (PYY) were measured pre- and postprandially. Plasma CGRP concentrations were lowered following the protein meal and following the fat meal, but remained unaltered after carbohydrate or water ingestion. Plasma VIP concentrations increased slightly following the carbohydrate meal and following water loading. The PYY concentrations increased after the protein and the carbohydrate meal and a slight rise was observed following fat ingestion. Water loading did not affect the plasma level of PYY. We conclude that the postprandial peripheral plasma concentrations of CGRP, VIP and PYY are dependent on the caloric meal composition. The VIP, but not the CGRP and PYY concentrations seem to be influenced by gastric distension. The physiological significance of the postprandial alterations in peripheral concentrations of these peptides is at present uncertain.
在一项随机交叉研究中，健康的非肥胖男性受试者接受了标准化的等热量、等体积餐食，这些餐食分别由碳水化合物、蛋白质或脂肪组成，以及一份由等量水组成的无热量对照餐。在餐前和餐后测量外周静脉血浆中降钙素基因相关肽（CGRP）、P物质（SP）、血管活性肠肽（VIP）和肽YY（PYY）的浓度。蛋白质餐和脂肪餐后血浆CGRP浓度降低，但碳水化合物或水摄入后保持不变。碳水化合物餐和饮水后血浆VIP浓度略有升高。蛋白质餐和碳水化合物餐后PYY浓度升高，脂肪摄入后观察到略有上升。饮水不影响血浆PYY水平。我们得出结论，餐后外周血浆中CGRP、VIP和PYY的浓度取决于餐食的热量组成。VIP浓度似乎受胃扩张影响，而CGRP和PYY浓度不受影响。目前这些肽在外周浓度餐后变化的生理意义尚不确定。
