多形核白细胞化学发光的年龄依赖性变化。
Age-dependent variations in polymorphonuclear leukocyte chemiluminescence.
作者信息
Van Epps D E, Goodwin J S, Murphy S
出版信息
Infect Immun. 1978 Oct;22(1):57-61. doi: 10.1128/iai.22.1.57-61.1978.
Polymorphonuclear leukocytes from 46 adults (age 18 to 35), 19 adults (age 70 to 91), 10 children (age 1 to 3), and 22 neonates (cord blood samples) were tested for their chemiluminescence response to opsonized zymosan. Results indicated that both cord blood leukocytes and those from individuals over 70 were significantly lower (P less than 0.05) in their chemiluminescence response. Furthermore, when the latter group was divided into two subsets, one containing subjects over 80 years of age and the other containing subjects between 70 and 80 years of age, those over 80 showed a chemiluminescence response significantly lower (P less than 0.05) than those between 70 and 80. The kinetics of the chemiluminescence response was similar with all samples except the neonatal cells, where the response appeared to peak and subside more slowly. These data demonstrate that polymorphonuclear leukocyte chemiluminescence is depressed in the very young and the very old.
对46名成年人（年龄18至35岁）、19名成年人（年龄70至91岁）、10名儿童（年龄1至3岁）和22名新生儿（脐带血样本）的多形核白细胞进行了测试，以检测其对调理酵母聚糖的化学发光反应。结果表明，脐带血白细胞和70岁以上个体的白细胞在化学发光反应方面均显著较低（P小于0.05）。此外，当将后一组分为两个亚组时，一个亚组包含80岁以上的受试者，另一个亚组包含70至80岁的受试者，80岁以上的受试者的化学发光反应显著低于（P小于0.05）70至80岁的受试者。除新生儿细胞外，所有样本的化学发光反应动力学相似，新生儿细胞的反应似乎达到峰值和消退的速度更慢。这些数据表明，多形核白细胞化学发光在非常年幼和非常年老的人群中受到抑制。
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