Carmagnol F, Sinet P M, Rapin J, Jerome H
Clin Chim Acta. 1981 Dec 9;117(2):209-17. doi: 10.1016/0009-8981(81)90040-1.
An assay for human erythrocyte glutathione-S-transferase is described. The procedure is both sensitive and reproducible; sampling and storage conditions are also investigated. Reference values are given for normal neonates, children and adults. The normal red cell glutathione-S-transferase activity decreases significantly during the first weeks of life and remains constant afterwards. A slight but significant increase is observed over 75 years. Sex difference has no influence on enzyme activity. A significant increase (up to fourfold) in red cell glutathione-S-transferase activity is noted in newborns with hyperbilirubinemia exceeding 135 mumol/l. Red cell glutathione-S-transferase is also significantly increased in hemodialysed subjects suffering from renal dysfunction.
本文描述了一种检测人红细胞谷胱甘肽 - S - 转移酶的方法。该方法灵敏且可重复；同时还研究了采样和储存条件。给出了正常新生儿、儿童和成人的参考值。正常红细胞谷胱甘肽 - S - 转移酶活性在生命的最初几周显著下降，之后保持稳定。75岁以上人群中观察到轻微但显著的升高。性别差异对酶活性无影响。在高胆红素血症超过135μmol/l的新生儿中，红细胞谷胱甘肽 - S - 转移酶活性显著升高（高达四倍）。在患有肾功能不全的血液透析患者中，红细胞谷胱甘肽 - S - 转移酶也显著升高。
