Mushahwar I K, Dienstag J L, Polesky H F, McGrath L C, Decker R H, Overby L R
Am J Clin Pathol. 1981 Dec;76(6):773-7. doi: 10.1093/ajcp/76.6.773.
Serial serum specimens from 149 patients with clinically diagnosed hepatitis were tested for five hepatitis B serological markers: hepatitis B surface antigen and its antibody (anti-HBs); hepatitis B e-antigen and its antibody (anti-HBe); and antibody to hepatitis B core antigen (anti-HBc). The times of appearance, disappearance, and persistence of these markers were used to differentiate various serological profiles obtained from the study. Four distinctive profiles were found to be associated with acute hepatitis B followed by recovery, and three with chronic hepatitis. These serologic profiles were assessed as diagnostic and prognostic guides for clinical management of the disease.
对149例临床诊断为肝炎的患者的系列血清标本进行了五项乙肝血清学标志物检测：乙肝表面抗原及其抗体（抗-HBs）；乙肝e抗原及其抗体（抗-HBe）；以及乙肝核心抗原抗体（抗-HBc）。这些标志物的出现、消失和持续时间用于区分研究中获得的各种血清学模式。发现有四种独特的模式与急性乙型肝炎后恢复相关，三种与慢性肝炎相关。这些血清学模式被评估为该疾病临床管理的诊断和预后指导。
