Hadler S C, Murphy B L, Schable C A, Heyward W L, Francis D P, Kane M A
J Clin Microbiol. 1984 Apr;19(4):521-5. doi: 10.1128/jcm.19.4.521-525.1984.
To determine the significance of certain serological test results commonly encountered in hepatitis B virus testing, we reviewed serological test data from nine studies of hepatitis B conducted between 1980 and 1982. Three tests, for hepatitis B surface antigen and for antibodies to hepatitis B surface antigen and hepatitis B core antigen (anti-HBs and anti-HBc), were used to measure hepatitis B virus infection risk in various populations. Two results, low levels of anti-HBs alone and low levels of anti-HBc alone, occurred at constant frequencies (2.72 and 0.4%, respectively), regardless of the prevalence of HBV infection in the population. Positivity for low levels of anti-HBs alone persisted for 1 year in less than one-half of those studied; in addition, response to hepatitis B virus vaccine was augmented in only one-third of this group. Positivity for low levels of anti-HBc alone did not persist in any of 11 persons studied. These findings indicate that presently available tests for anti-HBs and anti-HBc at low levels are often nonspecific and should be interpreted with caution.
为了确定乙肝病毒检测中常见的某些血清学检测结果的意义，我们回顾了1980年至1982年间进行的9项乙肝研究的血清学检测数据。使用三项检测，即针对乙肝表面抗原以及乙肝表面抗原和乙肝核心抗原抗体（抗-HBs和抗-HBc）的检测，来衡量不同人群感染乙肝病毒的风险。两项结果，即单独抗-HBs水平低和单独抗-HBc水平低，无论人群中HBV感染的流行率如何，均以恒定频率出现（分别为2.72%和0.4%）。单独抗-HBs水平低的阳性结果在不到一半的研究对象中持续了1年；此外，该组中只有三分之一的人对乙肝病毒疫苗的反应增强。单独抗-HBc水平低的阳性结果在11名研究对象中均未持续。这些发现表明，目前可用的低水平抗-HBs和抗-HBc检测通常是非特异性的，应谨慎解释。
