Nagy E, Berczi I
Allergy. 1981 Aug;36(6):429-31. doi: 10.1111/j.1398-9995.1981.tb01850.x.
Hypophysectomized (Hypo-X) rats did not develop contact dermatitis in response to dinitrochlorobenzene (DNCB). Syngeneic pituitary grafts placed under the kidney capsule or daily treatment with prolactin restored the DNCB-reactivity of Hypo-X animals. Combined treatment with other pituitary hormones was ineffective. Treatment of normal rats with a potent prolactin antagonist drug, bromocriptine, was as effective in inhibiting contact sensitivity as was hypophysectomy. These results indicate the contact sensitivity is a prolactin dependent reaction.
垂体切除的（Hypo-X）大鼠对二硝基氯苯（DNCB）不发生接触性皮炎。置于肾被膜下的同基因垂体移植或用催乳素每日治疗可恢复Hypo-X动物对DNCB的反应性。与其他垂体激素联合治疗无效。用一种强效催乳素拮抗剂药物溴隐亭治疗正常大鼠，在抑制接触敏感性方面与垂体切除同样有效。这些结果表明接触敏感性是一种依赖催乳素的反应。
