由异种大鼠刺激细胞诱导的小鼠细胞溶解T淋巴细胞对H-2复合体同种抗原具有特异性。
Mouse cytolytic T lymphocytes induced by xenogeneic rat stimulator cells exhibit specificity for H-2 complex alloantigens.
作者信息
Burakoff S J, Ratnofsky S E, Benacerraf B
出版信息
Proc Natl Acad Sci U S A. 1977 Oct;74(10):4572-6. doi: 10.1073/pnas.74.10.4572.
Abstract
When mouse spleen cells were stimulated with irradiated xenogeneic, allogeneic, or trinitrophenyl-modified syngeneic lymphoid cells, the strongest cytolytic response was induced by alloantigens. Mouse cytolytic T lymphocytes generated to rat lymphoid cells demonstrated specificity for the immunizing rat strain, but extensive lysis of allogeneic target cells from certain mouse strains was also observed. Cold target inhibition studies indicated that separate clones of xenoantigen-induced cytolytic T lymphocytes lysed each of the allogeneic murine targets. [3H]Thymidine suicide of the effector cells generated to the rat stimulators revealed that only some of all potentially reactive mouse cytolytic T lymphocyte precursors with specificity for a given allogeneic target are activated by the stimulation with rat cells. This evidence that xenoantigens induce alloreactive cytolytic T lymphocyte receptor repertoire is directed at variants of autologous major histocompatibility complex antigens.
摘要
当用经辐照的异种、同种异体或三硝基苯修饰的同基因淋巴细胞刺激小鼠脾细胞时，同种异体抗原诱导出最强的细胞溶解反应。针对大鼠淋巴细胞产生的小鼠细胞溶解T淋巴细胞对免疫大鼠品系具有特异性，但也观察到某些小鼠品系的同种异体靶细胞被广泛裂解。冷靶抑制研究表明，异种抗原诱导的细胞溶解T淋巴细胞的不同克隆裂解了每种同种异体小鼠靶细胞。对大鼠刺激物产生的效应细胞进行[3H]胸腺嘧啶核苷自杀实验表明，在用大鼠细胞刺激时，只有一些对给定同种异体靶细胞具有特异性的所有潜在反应性小鼠细胞溶解T淋巴细胞前体被激活。这一证据表明，异种抗原诱导的同种异体反应性细胞溶解T淋巴细胞受体库针对的是自体主要组织相容性复合体抗原的变体。
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Mouse cytolytic T lymphocytes induced by xenogeneic rat stimulator cells exhibit specificity for H-2 complex alloantigens.由异种大鼠刺激细胞诱导的小鼠细胞溶解T淋巴细胞对H-2复合体同种抗原具有特异性。
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The somatic generation of immune recognition.免疫识别的体细胞产生
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Cytolytic thymus-derived lymphocytes specific for allogeneic stimulator cells crossreact with chemically modified syngeneic cells.对同种异体刺激细胞具有特异性的溶细胞性胸腺来源淋巴细胞与化学修饰的同基因细胞发生交叉反应。
Proc Natl Acad Sci U S A. 1977 Mar;74(3):1229-33. doi: 10.1073/pnas.74.3.1229.
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Education of human lymphocytes against mouse cells: specific recognition of H-2 antigens.人淋巴细胞针对小鼠细胞的培养：H-2抗原的特异性识别。
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Specificity of virus-immune effector T cells for H-2K or H-2D compatible interactions: implications for H-antigen diversity.病毒免疫效应T细胞对H-2K或H-2D相容相互作用的特异性：对H抗原多样性的影响。
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