大鼠肾静脉流出液中中性抗高血压脂质的提取

Derivation of neutral antihypertensive lipid from renal venous effluent in rats.

Muirhead E E, Byers L W, Pitcock J A, Desiderio D M, Brooks B, Brown P, Brosius W L

Clin Sci (Lond). 1981 Dec;61 Suppl 7:331s-333s. doi: 10.1042/cs061331s.

Abstract

The antihypertensive neutral renomedullary lipid (ANRL) is a natural product derived from fresh renal medulla and from venous blood. 2. ANRL appears to be an antihypertensive hormone secreted when the kidney exerts its antihypertensive function after unclipping. 3. The kidney appears to be the main source of ANRL, maintaining a basal rate of secretion of ANRL. 4. The kidney of the one-kidney, one-clip hypertensive rat appears to secrete an inappropriate amount of ANRL. Thus a deficiency of the secretion of the antihypertensive hormone may play a role in the pathogenesis of the one-kidney, one-clip hypertensive model. 5. Degranulation of the renomedullary interstitial cells (RIC) occurs as the kidney exerts its antihypertensive action after unclipping, supporting these cells as the source of ANRL. 6. Channels between collecting duct cells may encourage water reabsorption while the clip is in place; conversely, the closure of these channels when the clip is removed may encourage the diuresis that is observed.

摘要

抗高血压中性肾髓质脂质（ANRL）是一种源自新鲜肾髓质和静脉血的天然产物。2. ANRL似乎是一种抗高血压激素，当肾脏在解除夹闭后发挥其抗高血压功能时分泌。3. 肾脏似乎是ANRL的主要来源，维持着ANRL的基础分泌率。4. 单肾单夹高血压大鼠的肾脏似乎分泌了不适当量的ANRL。因此，抗高血压激素分泌不足可能在单肾单夹高血压模型的发病机制中起作用。5. 肾髓质间质细胞（RIC）的脱颗粒发生在肾脏解除夹闭后发挥其抗高血压作用时，支持这些细胞作为ANRL的来源。6. 当夹子在位时，集合管细胞之间的通道可能促进水的重吸收；相反，当夹子移除时这些通道的关闭可能促进所观察到的利尿作用。