Pitcock J A
Department of Pathology, University of Tennessee, Memphis 38146.
Am J Med Sci. 1988 Apr;295(4):246-51. doi: 10.1097/00000441-198804000-00005.
The renomedullary interstitial cell (RIC) is a unique cell found in the renal medullary interstitium among the collecting ducts, Henle's loop, and the vasa recta. A combination of morphologic and physiologic studies has defined some of the properties of this cell, which is the apparent source of the mediators of the antihypertensive function of the kidney. These may include prostaglandins (PGE2), APRL or platelet activating factor, and the incompletely defined neutral lipid, ANRL (or medullipin), the most likely candidate for this function. The lipid droplets in the RIC apparently are the precursors of the mediator(s). Degranulation of the RIC by an experimental maneuver usually indicates increased activity of these cells. The presence of abundant well-granulated RIC in a kidney indicates a resistance of that animal to the induction of salt-sensitive forms of experimental hypertension. There is definite evidence for an extrarenal antihypertensive function of the RIC mediators, but an intrarenal effect also is considered.
肾髓质间质细胞（RIC）是一种独特的细胞，存在于肾髓质间质中，位于集合管、髓袢和直小血管之间。形态学和生理学研究相结合，已经明确了这种细胞的一些特性，它显然是肾脏降压功能介质的来源。这些介质可能包括前列腺素（PGE2）、APRL或血小板活化因子，以及定义不完全明确的中性脂质ANRL（或髓质素），它最有可能是发挥此功能的介质。RIC中的脂滴显然是这些介质的前体。通过实验操作使RIC脱颗粒通常表明这些细胞的活性增加。肾脏中存在大量颗粒丰富的RIC表明该动物对盐敏感性实验性高血压的诱导具有抵抗力。有确切证据表明RIC介质具有肾外降压功能，但也考虑其肾内作用。
