Tran M A, Dang T L, Berlan M
J Lipid Res. 1981 Nov;22(8):1271-6.
We have studied the effect of epinephrine and isoproterenol on free fatty acid (FFA) mobilization from bone marrow adipose tissue in dog tibia after constant-flow autoperfusion of the nutrient artery by ipsilateral femoral arterial blood. The perfusions of epinephrine (0.025 microgram/min) or isoproterenol (0.005 microgram/min) significantly increased the FFA level in the nutrient vein of the tibia. Moreover, our data demonstrate that in vitro the bone marrow adipose tissue was less responsive to catecholamines than omental adipose tissue. It can be concluded that bone marrow adipose tissue is able to release FFA after administration of catecholamines but to a lesser extent than in other adipose tissue (omental adipose tissue). These results support the hypothesis that the bone marrow adipose tissue is involved in local nutrition rather than in the total energy supply of the animal.
我们通过用同侧股动脉血对营养动脉进行恒流自身灌注，研究了肾上腺素和异丙肾上腺素对犬胫骨骨髓脂肪组织游离脂肪酸（FFA）动员的影响。灌注肾上腺素（0.025微克/分钟）或异丙肾上腺素（0.005微克/分钟）可显著提高胫骨营养静脉中的FFA水平。此外，我们的数据表明，体外骨髓脂肪组织对儿茶酚胺的反应性低于网膜脂肪组织。可以得出结论，给予儿茶酚胺后骨髓脂肪组织能够释放FFA，但程度低于其他脂肪组织（网膜脂肪组织）。这些结果支持了骨髓脂肪组织参与局部营养而非动物总能量供应的假说。
