Nitta S, Ohnuki T, Ohkuda K, Nakada T, Staub N C
Tohoku J Exp Med. 1981 Sep;135(1):43-9. doi: 10.1620/tjem.135.43.
Examining the internal discrepancies of three equations (Landis and Pappenheimer 1965) which represent the relationship between colloid osmotic pressures (COP) and normal human plasma proteins, the authors derived a corrected globulin equation: COPglb = 1.3c + 0.14c2 + 0.006c3 (COP: mmHg, c: protein content, g/100 ml), instead of their COPglb = 1.6c + 0.15c2 + 0.006c3, when A/G (albumin-globulin ratio) = 1.1 as they had described. Revising the former globulin equation again, based upon the current estimate of A/G = 1.8, we derived a new globulin equation. Our new plasma equation, consisting of their albumin equation and our revised globulin equation, is COPpl = alpha (2.8c + 0.18c2 + 0.012c3) + beta (0.9c + 0.12c2 + 0.004c3), where alpha and beta stand for albumin and globulin fraction, respectively. The last, being generalized for plasma with any protein compositions, and closely corresponded to the values directly measured in normal human plasma with variable protein compositions, we developed it on a nomogram for practical use.
通过研究表示胶体渗透压（COP）与正常人血浆蛋白之间关系的三个方程（Landis和Pappenheimer，1965）的内部差异，作者得出了一个校正后的球蛋白方程：COPglb = 1.3c + 0.14c2 + 0.006c3（COP：mmHg，c：蛋白质含量，g/100 ml），而不是他们所描述的当A/G（白蛋白-球蛋白比率）= 1.1时的COPglb = 1.6c + 0.15c2 + 0.006c3。基于目前对A/G = 1.8的估计，再次修正前一个球蛋白方程，我们得出了一个新的球蛋白方程。我们的新血浆方程，由他们的白蛋白方程和我们修正后的球蛋白方程组成，即COPpl = α(2.8c + 0.18c2 + 0.012c3) + β(0.9c + 0.12c2 + 0.004c3)，其中α和β分别代表白蛋白和球蛋白部分。最后，将其推广到具有任何蛋白质组成的血浆，并与在具有可变蛋白质组成的正常人血浆中直接测量的值密切对应，我们在列线图上开发了它以供实际使用。
