Double-blind capillaroscopic study of the activity of buflomedil in Raynaud's syndrome: a report on 80 cases.

A double-blind study was performed to compare the effects of buflomedil versus placebo on the capillaroscopic images of the nailbed before and after a cold test in 80 patients with Raynaud phenomenon. The results were scored according to the elements of capillaroscopy (number of capillaries, size, density). Buflomedil was found to significantly better than a placebo (p less than 0.02).