Inheritance of primary glaucoma in the beagle.

Primary glaucoma in the Beagle is inherited as an autosomal recessive trait. Twenty-six matings of affected x affected Beagles resulted in 77 offspring with glaucoma (38 males/39 females). Four matings of glaucomatous Beagles (1 male/3 females) x normal laboratory-quality Beagles (3 males/1 female) yielded 15 ocular normotensive Beagles (6 males/9 females). Three matings of glaucomatous Beagles (3 males/1 female) x carrier Beagles (1 male/2 females) produced 19 offspring; 8 exhibited glaucoma (2 males/6 females) and 11 were ocular normotensive (6 males/5 females).