Halberg E, Halberg F, Shankaraiah K
Chronobiologia. 1981 Oct-Dec;8(4):351-66.
A Nippon-Colin (model BP-203X) instrument was used for longitudinal monitoring of systolic and diastolic blood pressure and pulse, at 10-min or other intervals for 26 days and for a shorter span, by a healthy woman, 60 years of age, and her husband, 61 years of age, both following their usual routine in an academic setting and at home. Due to the quasi-portable nature of the instrument, it was possible on most mornings to bring it from the home by car to the laboratory at the University and to return it to the home on most evenings, for about 2 months. The sturdy instrument withstood transportation and functioned flawlessly for the spans investigated. While the lack of true portability is definitely a handicap of the instrument which precludes it from use in sports and during ambulation, the circumstance that measurements during certain excessive activities away from a given site are not feasible can lead to a more standardized assessment of the blood pressure profile in subjects who pursue sedentary occupations. The procedures of linear-nonlinear rhythmometry applied to the data from the woman covering 26-day spans each and her husband covering 3 days, partly at 10-min and 3-min intervals, respectively, reveal the feasibility of quantifying parameters of circadian rhythmicity rather consistently. Spans as short as 48-h, invariably for the case of systolic blood pressure and usually for the case of diastolic blood pressure, though with lesser consistency for heart rate, sufficed to assess the circadian rhythmic component of this couple in their sixties and may constitute an individualized reference standard for blood pressure monitoring by the elderly with a view of assessing blood pressure rhythm alteration before it may become pathogenetic.
使用一台日本 Colin（型号 BP - 203X）仪器，由一位 60 岁的健康女性及其 61 岁的丈夫，在学术环境和家中按照日常惯例，以 10 分钟或其他间隔对收缩压、舒张压和脉搏进行了 26 天的纵向监测，以及较短时间段的监测。由于该仪器具有准便携式的特性，在大约 2 个月的时间里，大多数早晨可以用车将其从家中带到大学实验室，大多数晚上再将其带回家里。这台坚固的仪器经受住了运输过程，并且在研究的时间段内运行完美。虽然缺乏真正的便携性绝对是该仪器的一个缺陷，使其无法用于运动和行走期间，但在特定远离给定地点的过度活动期间无法进行测量的情况，可能会导致对从事久坐职业的受试者的血压状况进行更标准化的评估。将线性 - 非线性节律测量程序应用于该女性长达 26 天的数据以及其丈夫长达 3 天的数据（分别部分以 10 分钟和 3 分钟的间隔），结果表明相当一致地量化昼夜节律参数是可行的。短至 48 小时的时间段，对于收缩压情况总是足够的，对于舒张压情况通常也是足够的，尽管心率的一致性稍差，这足以评估这对六十多岁夫妇的昼夜节律成分，并且可能构成老年人血压监测的个性化参考标准，以便在血压节律改变可能致病之前对其进行评估。
