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淋巴细胞在非免疫性实验性炎症中的作用。

Role of lymphocytes in non-immune experimental inflammation.

作者信息

Garcia-Leme J

出版信息

Agents Actions. 1981 Dec;11(6-7):597-602. doi: 10.1007/BF01978757.

DOI:10.1007/BF01978757
PMID:7340447
Abstract

The role of lymphocytes in acute, non-immune inflammation has been studied in rats. Using drug-induced leucopenia and cell transfer studies it was found that the reduced carrageenin paw oedema in leucopenic rats could be restored by a specific subclass of lymphocytes distinct from T and B lymphocytes. The inflammatory effect of these lymphocytes appears to be mediated by a factor, the release of which is inhibited by steroidal and non-steroidal anti-inflammatory drugs and antilymphocyte sera.

摘要

淋巴细胞在大鼠急性非免疫性炎症中的作用已得到研究。通过药物诱导的白细胞减少和细胞转移研究发现,白细胞减少的大鼠中角叉菜胶所致的爪肿胀减轻可通过一类不同于T淋巴细胞和B淋巴细胞的特定淋巴细胞亚群得以恢复。这些淋巴细胞的炎症效应似乎由一种因子介导,甾体类和非甾体类抗炎药以及抗淋巴细胞血清可抑制该因子的释放。

相似文献

1
Role of lymphocytes in non-immune experimental inflammation.淋巴细胞在非免疫性实验性炎症中的作用。
Agents Actions. 1981 Dec;11(6-7):597-602. doi: 10.1007/BF01978757.
2
Involvement of lymphocytes in non-immune inflammation: dual effect of glucocorticoids.淋巴细胞在非免疫性炎症中的作用:糖皮质激素的双重效应。
Agents Actions. 1985 Sep;16(6):552-7. doi: 10.1007/BF01983662.
3
The proinflammatory function of lymphocytes in non-immune inflammation: effect of steroidal and non-steroidal anti-inflammatory agents.淋巴细胞在非免疫性炎症中的促炎功能:甾体类和非甾体类抗炎药的作用
Br J Exp Pathol. 1977 Dec;58(6):703-11.
4
Do lymphocytes play a pro-inflammatory role in any pharmacological type of rat paw edema?淋巴细胞在任何药理学类型的大鼠爪肿胀中是否发挥促炎作用?
Braz J Med Biol Res. 1989;22(2):179-87.
5
Some characteristics of the participation of lymphocytes in non-immune inflammation.淋巴细胞参与非免疫性炎症的一些特征。
Br J Exp Pathol. 1982 Oct;63(5):463-71.
6
A proinflammatory factor in lymphocytes. Its role in the development of acute, non-immunological inflammatory reactions.淋巴细胞中的一种促炎因子。其在急性非免疫性炎症反应发展中的作用。
Br J Exp Pathol. 1976 Aug;57(4):377-86.
7
Lymphocytes in non-immune inflammation: a specific subclass of lymphoid cells?非免疫性炎症中的淋巴细胞:一类特定的淋巴细胞亚群?
Br J Exp Pathol. 1981 Apr;62(2):172-82.
8
Modulation by lymphocytes of the vascular effects caused by inflammatory mediators and carrageenin in the rat.淋巴细胞对炎症介质和角叉菜胶在大鼠体内所引起血管效应的调节作用。
Br J Exp Pathol. 1976 Oct;57(5):497-504.
9
Drug modulation of antigen-induced paw oedema in guinea-pigs: effects of lipopolysaccharide, tumour necrosis factor and leucocyte depletion.药物对豚鼠抗原诱导的爪肿胀的调节作用:脂多糖、肿瘤坏死因子和白细胞耗竭的影响。
Br J Pharmacol. 1994 May;112(1):111-6. doi: 10.1111/j.1476-5381.1994.tb13038.x.
10
Does the pro-inflammatory factor in lymphocytes (LpIF) explain the role of these cells in acute inflammation?淋巴细胞中的促炎因子(LpIF)能否解释这些细胞在急性炎症中的作用?
Agents Actions. 1976 Nov;6(6):690-3. doi: 10.1007/BF02026089.

引用本文的文献

1
Studies into the association between leucocyte accumulation and oedema formation.
Agents Actions. 1985 Dec;17(2):209-13. doi: 10.1007/BF01966594.

本文引用的文献

1
FATE OF THE LYMPHOCYTE.淋巴细胞命运
J Exp Med. 1921 Apr 30;33(5):593-600. doi: 10.1084/jem.33.5.593.
2
THE ANTIBODY RESPONSE OF RATS DEPLETED OF LYMPHOCYTES BY CHRONIC DRAINAGE FROM THE THORACIC DUCT.经胸导管慢性引流耗尽淋巴细胞的大鼠的抗体反应。
J Exp Med. 1963 Jan 31;117(2):303-20. doi: 10.1084/jem.117.2.303.
3
The recirculation of lymphocytes from blood to lymph in the rat.大鼠体内淋巴细胞从血液到淋巴的再循环。
J Physiol. 1959 Apr 23;146(1):54-69. doi: 10.1113/jphysiol.1959.sp006177.
4
The inflammatory responses of rats depleted of lymphocytes or with an artificial obstruction of the thoracic duct.淋巴细胞耗竭或胸导管人工阻塞的大鼠的炎症反应。
Br J Exp Pathol. 1980 Apr;61(2):176-85.
5
Lymphocytes in non-immune inflammation: a specific subclass of lymphoid cells?非免疫性炎症中的淋巴细胞:一类特定的淋巴细胞亚群?
Br J Exp Pathol. 1981 Apr;62(2):172-82.
6
Effect of thymectomy in adult mice on immunological responsiveness.成年小鼠胸腺切除对免疫反应性的影响。
Nature. 1965 Dec 25;208(5017):1337-8. doi: 10.1038/2081337a0.
7
An analysis of the effects of some types of anti-lymphocyte sera on contact hypersensitivity and certain models of inflammation.某些类型的抗淋巴细胞血清对接触性超敏反应及某些炎症模型影响的分析
Immunology. 1968 May;14(5):683-95.
8
Cytotoxic lymphocytes from rats depleted of thymus processed cells.来自胸腺处理细胞耗竭的大鼠的细胞毒性淋巴细胞。
Nat New Biol. 1971 Jul 21;232(29):80-2. doi: 10.1038/newbio232080a0.
9
2 anti-inflammatory components in antilymphocytic serum.抗淋巴细胞血清中的2种抗炎成分。
Nature. 1970 Jul 18;227(5255):276-7. doi: 10.1038/227276a0.
10
Separation of anti-inflammatory and immunosuppressive activities in heterologous antilymphocyte serum.异种抗淋巴细胞血清中抗炎和免疫抑制活性的分离
Nature. 1969 Jul 5;223(5201):86-7. doi: 10.1038/223086a0.