Leme J G, Bechara G H, Sudo L S
Br J Exp Pathol. 1977 Dec;58(6):703-11.
Leucopenia rendered rats unresponsive to various inflammatory stimuli. The intensity of the inflammatory response in such animals was restored by i.v. administration of suspensions of lymphocytes, but not of granulocytes. This restorative effect was blocked by both steroidal and non-steroidal anti-inflammatory drugs. Utilizing carrageenin to induce inflammatory responses in the rat's paw, the effect of these drugs on lymphocytes was observed in two circumstances. First, following incubation of the cells with the drugs in concentrations not exceeding the peak plasma levels estimated for these substances in man or laboratory animals; the effect of the drugs seemed selective, since anti-histamine and anti-serotonin agents, as well as amethopterin, were devoid of action. Second, when lymphocytes were collected from rats previously treated with the various anti-inflammatory agents, injected 6-hourly during periods of 18 and 36 h, respectively, for steroidal and non-steroidal anti-inflammatory substances. The total amounts given were lower than those required to produce consistent anti-inflammatory effects in normal animals, when the drug was given as a single dose before injection of the irritant. It is concluded that the pro-inflammatory function of lymphocytes in non-immune inflammation can be blocked by steroidal and non-steroidal anti-inflammatory agents.
白细胞减少使大鼠对各种炎症刺激无反应。通过静脉注射淋巴细胞悬液可恢复此类动物的炎症反应强度，但注射粒细胞悬液则无此效果。甾体类和非甾体类抗炎药均可阻断这种恢复作用。利用角叉菜胶诱导大鼠爪部的炎症反应，在两种情况下观察了这些药物对淋巴细胞的作用。第一，将细胞与浓度不超过人体或实验动物体内这些物质估计的血浆峰值水平的药物孵育后；药物的作用似乎具有选择性，因为抗组胺药、抗5-羟色胺药以及氨甲蝶呤均无作用。第二，当从分别在18小时和36小时内每6小时用各种抗炎剂处理过的大鼠收集淋巴细胞时，对于甾体类和非甾体类抗炎物质而言，给药总量低于在正常动物中注射刺激物前单次给药产生持续抗炎作用所需的量。得出的结论是，甾体类和非甾体类抗炎剂可阻断淋巴细胞在非免疫性炎症中的促炎功能。
