Leme J G, Bechara G H, Dos Santos R R
Br J Exp Pathol. 1976 Aug;57(4):377-86.
Drug-induced leucopenia renders rats hyporeactive to various inflammatory stimuli. Administration to leucopenic rats of suspensions of lymphocytes, sufficient to apparently correct the induced lymphocytopenia, led to a partial but marked reversal of the inhibited responses. Similar results were observed when lysates of lymphocytes or filtrates of the disintegrated cells were injected. Suspensions of polymorphonuclear granulocytes, on the contrary, were ineffective in producing a reversal of inhibited inflammatory reactions in leucopenic rats. The presence of a proinflammatory factor (LpIF) in lymphocytes, which might be involved in the modulation of acute inflammatory responses is suggested.
药物诱导的白细胞减少使大鼠对各种炎症刺激反应低下。给白细胞减少的大鼠注射足以明显纠正所诱导的淋巴细胞减少的淋巴细胞悬液，导致受抑制反应部分但显著逆转。当注射淋巴细胞裂解物或破碎细胞的滤液时，观察到类似结果。相反，多形核粒细胞悬液对逆转白细胞减少大鼠受抑制的炎症反应无效。提示淋巴细胞中存在一种促炎因子（LpIF），它可能参与急性炎症反应的调节。
