Sudo L S, Leme J G
Br J Exp Pathol. 1980 Apr;61(2):176-85.
Rats selectively depleted of lymphocytes by chronic drainage from the thoracic duct during a 3-day period presented a marked lymphopenia, and decreased responses to carrageenin injected into one of the hind paws. The intensity of the inflammatory responses in thse animals was restored by the i.v. administration of suspensions of viable or lysed lymphocytes, collected from the spleen or lymph of normal animals. A spontaneous reversal of the depressed responses to carrageenin was observed 40 days after the period of lymph drainage, when lymphocyte counts were again normal in blood. If highly inbred rats were used, the i.v. injection of syngeneic lymphoid cells was equally effective in restoring the inhibityed inflammatory responses resulting from lymphocyte depletion. Artificial obstruction of the thoracic duct, with interruption of lymphocyte recirculation, was followed by decreased lymphocyte counts in blood and severely depressed inflammatory responses to carrageenin. This unresponsive state was corrected as the animals recuperated, probably coincidentally with the development of collateral lymph channels and as the temporarily disturbed blood picture returned to normal. It is concluded that lymphocytes can participate in the development of non-immune inflammation through the release of pro-inflammatory factors. This release is independent of previous sensitization of the cells.
在3天时间内通过胸导管慢性引流而选择性地使淋巴细胞耗竭的大鼠呈现出明显的淋巴细胞减少，并且对注入一只后爪的角叉菜胶的反应减弱。通过静脉注射从正常动物的脾脏或淋巴中收集的活淋巴细胞或裂解淋巴细胞悬液，这些动物的炎症反应强度得以恢复。在淋巴引流期40天后观察到对角叉菜胶的反应性降低出现自发逆转，此时血液中的淋巴细胞计数再次正常。如果使用高度近交系大鼠，静脉注射同基因淋巴细胞在恢复因淋巴细胞耗竭而受到抑制的炎症反应方面同样有效。胸导管的人工阻塞以及淋巴细胞再循环的中断，随后血液中的淋巴细胞计数减少，对角叉菜胶的炎症反应严重减弱。随着动物恢复，这种无反应状态得到纠正，这可能与侧支淋巴通道的形成巧合，并且随着暂时紊乱的血象恢复正常。得出的结论是，淋巴细胞可以通过释放促炎因子参与非免疫性炎症的发展。这种释放与细胞先前的致敏无关。
