Lorimer W V, Lilis R, Fischbein A, Daum S, Anderson H, Wolff M S, Selikoff I J
Scand J Work Environ Health. 1978;4 Suppl 2:220-6.
Styrene monomer is a greatly used chemical, chiefly in the production of polystyrene. A cross-sectional health survey of 493 production workers was undertaken at the oldest and largest monomer production, polymerization, and extrusion facility in the United States. Relative exposure durations and levels were obtained from occupational histories and corroborated by spot air sampling, blood and fat styrene concentrations and levels of urinary mandelic and phenylglyoxylic acids. Statistically significant differences between the prevalence of abnormalities in high and low exposure groups were found for the following: history of acute prenarcotic symptoms, history of acute lower respiratory symptoms, peroneal nerve conduction velocities, relative lymphocytosis, and elevated gamma glutamyl transpetsidase. The following showed no distinct pattern in prevalence when analyzed by exposure group: chest radiographic changes; indices or restrictive, obstructive and small airway dysfunction; other hepatic and hematological parameters; carcinoembryonic antigen level; sputum cytopathology; radial nerve conduction velocities; and ophthalmological findings. Clinically significant abnormalities were rare.
苯乙烯单体是一种广泛使用的化学品，主要用于生产聚苯乙烯。在美国最古老、最大的单体生产、聚合和挤出设施中，对493名生产工人进行了横断面健康调查。通过职业史获得相对暴露持续时间和水平，并通过现场空气采样、血液和脂肪中苯乙烯浓度以及尿中扁桃酸和苯乙醛酸水平进行佐证。在高暴露组和低暴露组之间，发现以下方面的异常患病率存在统计学显著差异：急性麻醉前症状史、急性下呼吸道症状史、腓总神经传导速度、相对淋巴细胞增多症以及γ-谷氨酰转肽酶升高。按暴露组分析时，以下方面在患病率上未显示出明显模式：胸部X光片变化；限制性、阻塞性和小气道功能障碍指标；其他肝脏和血液学参数；癌胚抗原水平；痰细胞病理学；桡神经传导速度；以及眼科检查结果。具有临床意义的异常情况很少见。
