苯乙烯聚合过程中的血液苯乙烯和尿液代谢物
Blood styrene and urinary metabolites in styrene polymerisation.
作者信息
Wolff M S, Lorimer W V, Lilis R, Selikoff I J
出版信息
Br J Ind Med. 1978 Nov;35(4):318-29. doi: 10.1136/oem.35.4.318.
Abstract
The results of the analysis of blood and urine samples for styrene and its metabolites in 491 workers in a styrene polymerisation plant in the United States are reported. The levels of exposure to styrene were estimated to be less than 10 ppm, but nevertheless styrene and metabolites were detectable in more than 50% of workers in polymerisation jobs, within 4 h of exposure. Workers involved in the manufacture and purification of styrene from ethyl benzene also had detectable blood styrene and urinary metabolites in 83% of recently exposed subjects. The relationship between styrene in blood and in subcutaneous fat and urinary metabolites as pharmacokinetic variables is discussed.
摘要
报告了对美国一家苯乙烯聚合厂491名工人的血液和尿液样本进行苯乙烯及其代谢物分析的结果。据估计，苯乙烯的接触水平低于10 ppm，但尽管如此，在接触后4小时内，超过50%的从事聚合工作的工人中仍可检测到苯乙烯及其代谢物。在最近接触过的受试者中，83%参与从乙苯制造和提纯苯乙烯的工人血液中的苯乙烯和尿液代谢物也可检测到。讨论了血液和皮下脂肪中的苯乙烯与尿液代谢物作为药代动力学变量之间的关系。
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