Galin M A, Turkish L, Chowchuvech E
Am J Ophthalmol. 1977 Aug;84(2):153-9. doi: 10.1016/0002-9394(77)90847-9.
Gas-liquid chromatography, infrared spectroscopy, or Raman spectroscopy were used to determine the level of monomer in intraocular lenses and in the preforms used in each step of the manufacturing process. Heating, lathing, molding, and grinding caused an increase in monomer content, presumably the result of depolymerization. The tendency of methylmethacrylate to volatilize, repolymerize, or dissolve precludes high monomer contents from persisting in intraocular lenses. Vacuum ovens or water baths significantly reduced the monomer content to levels of 0.5% or less. Lenses with a monomer content higher than that found in currently available commercial lenses had no effect on rabbit kidney cell cultures. Lens fragments with a similarly elevated monomer content were indistinguishable from lenses with a low monomer content in rabbit eyes. According to these data, monomer does not appear to be a toxic agent in currently available intraocular lenses.
采用气液色谱法、红外光谱法或拉曼光谱法来测定人工晶状体及制造过程各步骤中使用的预成型件中的单体含量。加热、车削、模塑和研磨会导致单体含量增加，这可能是解聚的结果。甲基丙烯酸甲酯的挥发、再聚合或溶解趋势使得高单体含量无法在人工晶状体中持续存在。真空烘箱或水浴可将单体含量显著降低至0.5%或更低水平。单体含量高于当前市售晶状体的人工晶状体对兔肾细胞培养物没有影响。单体含量同样升高的晶状体碎片在兔眼中与单体含量低的晶状体并无差异。根据这些数据，在当前市售的人工晶状体中，单体似乎不是一种有毒物质。
