Moore J G, Crespin F
Dig Dis Sci. 1980 Feb;25(2):117-22. doi: 10.1007/BF01308309.
Gastric acid secretion was stimulated by the preparation and anticipation of a self-selected meal in five healthy male subjects. The purpose of the investigation was to determine whether intravenous (IV) or intraduodenally (ID) administered glucose solution given during the test hour of meal preparation and anticipation altered psychically stimulated acid secretion. Each subject had seven self-selected meals and received in a randomized, blinded manner the following IV or ID solutions during the test hour: IV normal saline (200 ml/hr and 1000 ml/hr; N = 2); IV glucose, 10 g (200 ml/hr, 5% D/W; N = 1); IV glucose, 25 g (250 ml/hr, 10% D/W; N = 1); IV glucose, 100 g (1000 ml/hr 10% D/W: N = 1); ID normal saline (1000 ml/hr; N = 1) and ID glucose, 30-100 g (600-2000 ml/hr, 5% D/W; N = 1). Analysis of results revealed that only ID glucose significantly inhibited psychically stimulated acid secretion at doses and resultant plasma glucose concentrations considered physiological.
在五名健康男性受试者中，自行选择的餐食的准备和预期会刺激胃酸分泌。本研究的目的是确定在餐食准备和预期的测试时间内静脉注射（IV）或十二指肠内（ID）给予葡萄糖溶液是否会改变精神刺激引起的胃酸分泌。每位受试者有七次自行选择的餐食，并在测试时间内以随机、盲法的方式接受以下静脉或十二指肠内溶液：静脉注射生理盐水（200毫升/小时和1000毫升/小时；N = 2）；静脉注射葡萄糖10克（200毫升/小时，5%葡萄糖水溶液；N = 1）；静脉注射葡萄糖25克（250毫升/小时，10%葡萄糖水溶液；N = 1）；静脉注射葡萄糖100克（1000毫升/小时，10%葡萄糖水溶液：N = 1）；十二指肠内注射生理盐水（1000毫升/小时；N = 1）和十二指肠内注射葡萄糖30 - 100克（600 - 2000毫升/小时，5%葡萄糖水溶液；N = 1）。结果分析显示，仅十二指肠内注射葡萄糖在被认为是生理剂量和由此产生的血浆葡萄糖浓度下能显著抑制精神刺激引起的胃酸分泌。
