MacGregor I L, Deveney C, Way L W, Meyer J H
Gastroenterology. 1976 Feb;70(2):197-202.
The effects of hyperglycemia on pancreatic, biliary, and gastric secretory responses to meals have not been hitherto quantified in man. In the present study seven normal volunteers were fed on two occasions a 500-ml liquid test meal containing fat and protein. During one of the meals the subjects were made acutely hyperglycemic with intravenous glucose, whereas in control experiments, each subject received intravenous saline in place of glucose. A jejunal perfusion method was used to measure pancreatic outputs of trypsin and biliary outputs of bile salts for 150 min after the meal; the same method was used to quantify indirectly the amount of acid secreted by the stomach in the 150-min period. Serum gastrins were also measured basally and at intervals after the meal. Hyperglycemia suppressed serum gastrin, gastric acid production, trypsin secretion, and bile salt output in response to the test meal.
高血糖对人体进食后胰腺、胆汁和胃分泌反应的影响迄今尚未得到量化。在本研究中，七名正常志愿者分两次进食含脂肪和蛋白质的500毫升液体试验餐。在其中一次进餐期间，通过静脉注射葡萄糖使受试者急性血糖升高，而在对照实验中，每个受试者接受静脉注射生理盐水代替葡萄糖。采用空肠灌注法在进餐后150分钟测量胰蛋白酶的胰腺分泌量和胆汁盐的胆汁分泌量；用同样的方法间接量化150分钟内胃分泌的酸量。还在进餐前和进餐后定期测量血清胃泌素。高血糖抑制了试验餐引起的血清胃泌素、胃酸分泌、胰蛋白酶分泌和胆汁盐分泌。
