硬皮病中的毛细血管改变。
Capillary alterations in scleroderma.
作者信息
Fleischmajer R, Perlish J S
出版信息
J Am Acad Dermatol. 1980 Feb;2(2):161-70. doi: 10.1016/s0190-9622(80)80396-3.
Electron microscopy of capillaries was performed in scleroderma skin. The main alterations were (1) gaps, vacuolization and eventual destruction of endothelial cells, (2) reduplication of the basal lamina, (3) perivascular cellular infiltrates consisting of lymphocytes, plasma cells, macrophages, or monocytes, and (4) fibroblasts and pericytes with enlarged, rough endoplasmic reticulum (RER) accompanied by perivascular fibrosis. Perivascular cellular infiltrates and endothelial cell damage appear to precede the stage of fibrosis.
对硬皮病皮肤的毛细血管进行了电子显微镜检查。主要改变包括：（1）内皮细胞间隙、空泡化及最终破坏；（2）基底膜重复；（3）血管周围细胞浸润，由淋巴细胞、浆细胞、巨噬细胞或单核细胞组成；（4）成纤维细胞和周细胞，其粗面内质网（RER）增大，伴有血管周围纤维化。血管周围细胞浸润和内皮细胞损伤似乎先于纤维化阶段出现。
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