Wetzel W, Getsova V M, Jork R, Matthies H
Pharmacol Biochem Behav. 1980 Feb;12(2):319-22. doi: 10.1016/0091-3057(80)90378-0.
The effect of serotonin (5-HT) on consolidation of a brightness discrimination reaction was investigated in rats. Five microgram 5-HT, injected intrahippocampally immediately after training, impaired retention of the brightness discrimination tested 24 hr later. In biochemical experiments, leucine incorporation into hippocampal proteins in vivo was 32% inhibited by 5 microgram 5-HT. Leucine incorporation into proteins of hippocampal slices in vitro was decreased by 5 x 10(-5)M 5-HT. The results seem to support Essman's assumption that inhibition of brain protein synthesis by 5-HT may be responsible for the memory impairment. But also some other possibilities for a mechanism of 5-HT amnesia must be discussed.
研究了血清素（5-羟色胺，5-HT）对大鼠亮度辨别反应巩固的影响。训练后立即海马内注射5微克5-HT，会损害24小时后测试的亮度辨别记忆保持。在生化实验中，5微克5-HT在体内对海马蛋白质中亮氨酸掺入的抑制率为32%。体外实验中，5×10⁻⁵M的5-HT可降低海马切片蛋白质中亮氨酸的掺入。这些结果似乎支持埃斯曼的假设，即5-HT对脑蛋白质合成的抑制可能是记忆损害的原因。但5-HT致遗忘机制的其他一些可能性也必须加以讨论。
