Wetzel W, Popov N, Lössner B, Schulzeck S, Honza R, Matthies H
Pharmacol Biochem Behav. 1980 Dec;13(6):765-71. doi: 10.1016/0091-3057(80)90204-x.
The intraperitoneal or intraventricular application of L-fucose (100 mg/kg or 75 microgram, respectively) prior to training in shuttle box avoidance as well as in shock-motivated brightness discrimination in rats significantly improved the retention of learned behavior 24 hr later. The application of D-fucose was without influence on retention. In naive animals, intraventricularly applied L-fucose (75-200 microgram) caused an increase in the rate of protein synthesis in the hippocampus, resulting in a significant increase in total proteins of this brain structure, mainly attributed to the Tris-insoluble protein fractions. The results are discussed in terms of an activation of glycoprotein formation by increasing supply with L-fucose.
在大鼠进行穿梭箱回避训练以及电击驱动的亮度辨别训练之前，腹腔内或脑室内分别注射L-岩藻糖（100mg/kg或75μg），能显著提高24小时后习得行为的保持率。注射D-岩藻糖对保持率没有影响。在未受过训练的动物中，脑室内注射L-岩藻糖（75 - 200μg）会导致海马体中蛋白质合成速率增加，使该脑结构中的总蛋白显著增加，主要归因于三羟甲基氨基甲烷不溶性蛋白组分。从通过增加L-岩藻糖供应来激活糖蛋白形成的角度对这些结果进行了讨论。
